Related Experiment Video
Updated: Sep 20, 2025
14:26
A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
Published on: April 7, 2014
15.6K
Immunoprotecting Effects of Exercise Program against Ovarian Cancer: A Single-Blind, Randomized Controlled Trial
Jong-Kyun Lee1, Sihwa Park2, Yong-Seok Jee1,2
1Research Institute of Cell Immunity for Cancers, Seoul Songdo Hospital, Seoul 10083, Korea.
Cancers
|June 10, 2022
Summary
Exercise training significantly improved body composition and physical fitness in ovarian cancer survivors. This led to enhanced immune cell counts, including natural killer (NK) and natural killer T (NKT) cells, boosting innate immunity.
Area of Science:
- Oncology
- Immunology
- Exercise Science
Background:
- Limited research exists on exercise's impact on ovarian cancer survivors' immune function.
- Exercise is recognized for improving immune function in other cancer survivor populations.
Purpose of the Study:
- To investigate the effects of a 12-week exercise training program on physical fitness and innate immunity in ovarian cancer survivors (OCS).
Main Methods:
- Twenty-seven OCS were divided into a control group (COG) and an exercise group (EXG).
- The EXG engaged in regular exercise 6 days/week for 12 weeks.
- Evaluated changes in body composition, physical fitness, and immune cell counts (leukocytes, lymphocytes, NK, NKT cells).
Main Results:
- The exercise group showed significant decreases in body weight, fat mass, and BMI, with increased muscle mass compared to the control group.
- Positive changes in physical fitness were observed in the exercise group.
- Exercise training increased lymphocyte and neutrophil counts, as well as total natural killer (NK) and natural killer T (NKT) cell counts.
Conclusions:
- Twelve weeks of exercise training improved body composition and physical fitness in ovarian cancer survivors.
- Exercise enhanced innate immunity by increasing specific NK cell receptors (NKG2D+) and decreasing others (KIR2DL3+).
Related Concept Videos
01:30Hormonal Control of the Ovarian Cycle
3.5K
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
3.5K
02:07Oogenesis
64.5K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
64.5K
01:20Exercise and Cardiovascular Response
1.1K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
1.1K
01:27Tumor Immunotherapy
677
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
677