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New Developments in Carbonic Anhydrase IX-Targeted Fluorescence and Nuclear Imaging Agents.

Kuo-Ting Chen1, Yann Seimbille2,3

  • 1Department of Chemistry, National Dong Hwa University, Hualien 974301, Taiwan.

International Journal of Molecular Sciences
|June 10, 2022
PubMed
Summary

Carbonic anhydrase IX (CAIX) is a key biomarker for imaging tumors. New CAIX-targeted probes are advancing nuclear and optical imaging for better cancer diagnosis and surgical guidance.

Keywords:
PETSPECTcancercarbonic anhydrase IXfluorescence imagingimaging agents

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Area of Science:

  • Oncology
  • Biomedical Imaging
  • Molecular Biology

Background:

  • Carbonic anhydrase IX (CAIX) is a hypoxia-induced biomarker specific to solid tumors.
  • CAIX-targeted imaging holds significant clinical potential for cancer diagnosis and treatment assessment.

Purpose of the Study:

  • To review recent advancements in CAIX-targeted molecular imaging probes.
  • To discuss the application of these probes in nuclear and optical imaging modalities.

Main Methods:

  • Review of CAIX-targeted probes including monoclonal antibodies, antibody fragments, peptides, and small molecules.
  • Focus on probes for single-photon emission computerized tomography (SPECT), positron emission tomography (PET), and near-infrared fluorescence imaging (NIRF).

Main Results:

  • Development of diverse CAIX-targeted probes for various imaging techniques.
  • Demonstrated utility of nuclear imaging for non-invasive diagnosis and treatment response assessment.
  • Highlighted the role of intraoperative optical fluorescence imaging in surgical tumor delineation.

Conclusions:

  • CAIX-targeted probes are crucial for advancing cancer molecular imaging.
  • Continued development is needed to address current limitations and optimize clinical application.