Related Experiment Video

Updated: Sep 20, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

6.8K

Roles of Notch Signaling in the Tumor Microenvironment

Antonino B D'Assoro1, Roberto Leon-Ferre1, Eike-Benjamin Braune2

  • 1Mayo Clinic Cancer Center, Rochester, MN 55905, USA.

International Journal of Molecular Sciences
|June 10, 2022
PubMed

Insights

The Notch signaling pathway regulates cell fate and is crucial for development. Aberrant Notch signaling in the tumor microenvironment influences cancer progression and interactions between tumor and stromal cells, offering new therapeutic targets.

Area of Science:

  • Oncology
  • Cell Signaling
  • Cancer Biology

Background:

  • The Notch signaling pathway is vital for cell fate determination and tissue homeostasis.
  • Dysregulation of Notch signaling is linked to various cancers, with pathway proteins acting as oncogenes or tumor suppressors.
  • Emerging evidence highlights Notch signaling's role in non-mutated tumor microenvironment cells.

Purpose of the Study:

  • To review the role of aberrant Notch signaling in tumor stroma cells.
  • To explore how Notch signaling affects cancer-associated fibroblasts, immune cells, and vascular cells.
  • To understand the impact of Notch signaling on tumor-stroma interactions and potential therapeutic strategies.

Main Methods:

  • Literature review of studies on Notch signaling in cancer.
  • Analysis of Notch pathway's influence on tumor microenvironment components.
  • Synthesis of information on tumor-stroma interactions modulated by Notch signaling.

Main Results:

  • Aberrant Notch signaling impacts cancer-associated fibroblasts, immune cells, and vascular cells within the tumor stroma.
  • Notch signaling influences the interactions between tumor cells and stromal cells.
  • The role of Notch signaling extends beyond tumor cells to the surrounding microenvironment.

Conclusions:

  • Understanding Notch signaling in the tumor environment is key to comprehending cancer progression.
  • Targeting Notch signaling in stromal cells presents a promising avenue for novel cancer therapies.
  • Further research into Notch-mediated tumor-stroma interactions can lead to improved therapeutic strategies.
Keywords:
Notch signalingcanceroncogenetumortumor microenvironmenttumor suppressor gene

More Related Videos

Stimulation of Notch Signaling in Mouse Osteoclast Precursors08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

8.0K
Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo08:19

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

6.1K

Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.5K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.2K
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.8K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.7K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.6K