Related Experiment Video

Updated: Sep 20, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

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Notch Signaling in Breast Tumor Microenvironment as Mediator of Drug Resistance

Adele Chimento1, Maria D'Amico1,2, Vincenzo Pezzi1

  • 1Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, CS, Italy.

International Journal of Molecular Sciences
|June 10, 2022
PubMed

Insights

Notch signaling promotes breast cancer progression and drug resistance by affecting the tumor microenvironment. Targeting Notch may reverse resistance and reduce cancer stem cells.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Notch signaling pathway dysregulation drives breast cancer progression.
  • Notch signaling influences tumor-stroma interactions and cellular heterogeneity.
  • Aberrant Notch activation contributes to breast cancer drug resistance.

Purpose of the Study:

  • To review the role of Notch activation in the breast tumor microenvironment.
  • To summarize Notch signaling's involvement in angiogenesis, extracellular matrix remodeling, and immune system interplay.
  • To highlight Notch's contribution to therapy resistance mechanisms.

Main Methods:

  • Literature review of preclinical studies and scientific evidence.
  • Analysis of Notch pathway's role in breast cancer progression and resistance.
  • Synthesis of current research on Notch signaling in the tumor microenvironment.

Main Results:

  • Notch signaling promotes stem cell maintenance, proliferation, and migration.
  • Notch pathway dysregulation remodels the tumor microenvironment, fostering resistance.
  • Targeting Notch shows potential in preventing or reversing drug resistance.

Conclusions:

  • Notch signaling is a key driver of breast cancer progression and therapy resistance.
  • Understanding Notch's role in the tumor microenvironment is crucial for developing new therapies.
  • Targeting Notch signaling presents a promising strategy to overcome breast cancer drug resistance.
Keywords:
JAGRBPJcancer-associated fibroblaststumor-associated macrophagesγ-secretase

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