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Significant Decrease in the Prevalence of Anxiety and Depression after Hepatitis C Eradication.

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Direct-Acting Agents (DAA) significantly reduced anxiety and depression in chronic hepatitis C (HCV) patients. This HCV treatment improved mental health and overall quality of life, highlighting the need for continued screening and care.

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Area of Science:

  • Hepatology and Viral Gastroenterology
  • Psychiatry and Mental Health
  • Public Health and Epidemiology

Background:

  • Chronic hepatitis C (HCV) poses an ongoing global health challenge, with potential neurological and psychological complications.
  • HCV infection can negatively impact mental health, exacerbating conditions like anxiety and depression.
  • Highly effective Direct-Acting Agents (DAA) offer a pathway to HCV eradication, but widespread undiagnosed infections necessitate enhanced screening.

Purpose of the Study:

  • To evaluate the prevalence of anxiety and depression in patients with chronic hepatitis C.
  • To assess the impact of Direct-Acting Agents (DAA) treatment on mental health outcomes and health-related quality of life (HRQoL) in HCV patients.
  • To explore the correlation between anxiety, depression, and HRQoL before and after DAA therapy in a real-world setting.

Main Methods:

  • A single-center study in Poland involving 90 patients diagnosed with chronic hepatitis C.
  • Data collection utilized self-reported questionnaires to assess anxiety, depression, and health-related quality of life (HRQoL).
  • Measurements were taken before and after the administration of Direct-Acting Agents (DAA) treatment.

Main Results:

  • HCV eradication through DAA therapy led to a significant decrease in anxiety prevalence (30.4% to 19.1%) and depression (35.2% to 18.2%).
  • Patients experienced significant improvements in multiple domains of The World Health Organization Quality of Life-BREF (WHOQOL-BREF) and Hepatitis Quality of Life Questionnaire version 2 (HQLQ v.2).
  • Both anxiety and depression were found to significantly diminish scores across somatic, psychological, social, and environmental domains of quality of life.

Conclusions:

  • Direct-Acting Agents (DAA) treatment is highly effective in improving mental health and quality of life for patients with chronic hepatitis C (HCV).
  • The study underscores the significant negative impact of anxiety and depression on the overall well-being of HCV patients.
  • Active case-finding strategies for HCV are crucial, particularly targeting individuals receiving psychiatric and psychological care.