Related Experiment Video

Updated: Sep 20, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

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Clinicopathological Patterns and Outcomes in Patients with Lupus Nephritis and Hyperuricemia

Qiong Wen1,2,3, Xueqing Tang1,2,3,4, Qian Zhou5

  • 1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.

Journal of Clinical Medicine
|June 10, 2022
PubMed

Insights

Hyperuricemia (HUA) in lupus nephritis (LN) patients is common and associated with worse clinicopathological features. However, HUA did not independently predict poor renal outcomes or mortality in this large cohort study.

Area of Science:

  • Nephrology
  • Rheumatology
  • Internal Medicine

Background:

  • Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus.
  • Hyperuricemia (HUA) is frequently observed in LN patients, but its impact on prognosis is debated.
  • Limited large cohort data exist on clinicopathological characteristics and outcomes of LN with HUA.

Purpose of the Study:

  • To investigate the clinicopathological features and prognosis of lupus nephritis patients with hyperuricemia.
  • To determine if hyperuricemia is an independent risk factor for adverse renal outcomes and mortality in LN.

Main Methods:

  • Retrospective cohort study of 1297 LN patients from January 1996 to December 2011.
  • Analysis of clinical, laboratory, pathological data, and long-term renal endpoint events and mortality.
  • Comparison between patients with and without hyperuricemia.

Main Results:

  • Hyperuricemia (HUA) was present in 50.04% of LN patients.
  • HUA patients exhibited higher blood pressure, triglycerides, lupus activity, and more severe renal pathology (crescents, inflammation).
  • No significant difference in 5- and 10-year renal endpoint event rates or mortality between HUA and non-HUA groups.

Conclusions:

  • Hyperuricemia in lupus nephritis patients is associated with more severe disease manifestations and pathological findings.
  • Hyperuricemia is not an independent risk factor for poor clinical outcomes or mortality in LN patients.
  • Steroid treatment did not influence survival despite delaying renal function deterioration.

Keywords:
hyperuricemialupus nephritisoutcomesrisk factorsuric acid

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