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Three-Dimensional Bioprinting of Decellularized Extracellular Matrix-Based Bioinks for Tissue Engineering
Chun-Yang Zhang1,2, Chao-Ping Fu1,2, Xiong-Ya Li1,2
1Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China.
Molecules (Basel, Switzerland)
|June 10, 2022
Summary
Decellularized extracellular matrix (dECM) bioinks are revolutionizing 3D bioprinting for tissue engineering. These advanced bioinks offer unique biochemical properties for creating complex, cell-laden tissue constructs.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Additive Manufacturing
Background:
- Three-dimensional (3D) bioprinting utilizes bioinks, mixtures of biomaterials and cells, to fabricate tissue and organ architectures.
- Decellularized extracellular matrix (dECM)-based bioinks are gaining traction due to their inherent biomimetic properties.
Purpose of the Study:
- To review the fundamental aspects of natural ECM and its biological functions.
- To discuss decellularization methods and quality control for dECM.
- To summarize dECM bioink preparation, 3D bioprinting techniques, and applications in tissue engineering.
Main Methods:
- Review of existing literature on ECM, decellularization, bioink formulation, and 3D bioprinting.
- Analysis of dECM properties and their impact on cell behavior.
- Synthesis of current applications and future challenges in dECM-based tissue engineering.
Main Results:
- Natural ECM provides essential biochemical cues for cell growth and metabolism.
- Various decellularization techniques exist, requiring rigorous quality control for dECM integrity.
- dECM bioinks can be prepared using diverse strategies and printed using multiple 3D bioprinting methods.
Conclusions:
- 3D bioprinted dECM bioinks show significant potential for tissue engineering applications.
- Addressing current challenges in dECM bioink development and bioprinting processes is crucial for future advancements.
