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Natural Products in Preventing Tumor Drug Resistance and Related Signaling Pathways

Chuansheng Yang1, Zhikai Mai2,3, Can Liu2,3

  • 1Department of Head-Neck and Breast Surgery, Yuebei People's Hospital of Shantou University, Shaoguan 512027, China.

Molecules (Basel, Switzerland)
|June 10, 2022
PubMed

Insights

Natural products offer promising strategies to overcome tumor drug resistance in cancer therapy. This review explores natural product inhibitors targeting key signaling pathways involved in drug resistance, providing new avenues for treatment.

Area of Science:

  • Oncology
  • Pharmacology
  • Natural Products Research

Background:

  • Drug resistance remains a significant challenge in cancer therapy, often leading to treatment failure.
  • Identifying novel strategies to overcome tumor drug resistance is a critical area of cancer research.
  • Natural products, with their diverse chemical structures and bioactivities, show potential in combating drug resistance.

Purpose of the Study:

  • To review signaling pathways implicated in the development of tumor drug resistance.
  • To identify natural product-derived inhibitors targeting these resistance pathways.
  • To offer new perspectives for preventing and treating drug-resistant cancers.

Main Methods:

  • Literature review of signaling pathways involved in cancer drug resistance.
  • Identification and categorization of natural products and their derivatives that inhibit these pathways.
  • Analysis of the mechanisms by which natural products counteract drug resistance.

Main Results:

  • Key signaling pathways such as Epidermal growth factor receptor (EGFR), Renin-angiotensin system (Ras), Phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt), Wnt, Notch, and Transforming growth factor-beta (TGF-β) are involved in drug resistance.
  • Various natural products and their derivatives exhibit inhibitory effects on these pathways.
  • These natural compounds demonstrate potential in overcoming multidrug resistance in cancer.

Conclusions:

  • Natural products are valuable resources for developing novel anti-cancer drugs that can circumvent drug resistance.
  • Targeting specific signaling pathways with natural product-derived inhibitors presents a promising strategy for enhancing cancer therapy efficacy.
  • Further research into natural products can lead to innovative approaches for managing drug-resistant tumors.
Keywords:
drug resistancemechanismsignaling pathwaytumor

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