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Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products

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Yeast Particles Hyper-Loaded with Terpenes for Biocide Applications.

Ernesto R Soto¹, Florentina Rus¹, Gary R Ostroff¹

¹Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Molecules (Basel, Switzerland)

|June 10, 2022

Summary

Researchers developed hyper-loaded yeast particles (YPs) for enhanced terpene delivery. These improved YPs offer higher loading capacity, extended release, and greater stability for agricultural and pharmaceutical applications.

Keywords:

biocide controlled delivery microencapsulation terpenes yeast particles

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Area of Science:

Biotechnology
Materials Science
Agricultural Science

Background:

Yeast particles (YPs) are porous microspheres derived from yeast extract.
YPs can encapsulate terpenes via passive diffusion.
Previous YP formulations have applications in agriculture and pharmaceuticals.

Purpose of the Study:

To develop methods for increasing terpene loading capacity in YPs.
To enhance the stability and release kinetics of encapsulated terpenes.
To explore applications of hyper-loaded YP-terpene compositions.

Main Methods:

Investigated methods to increase terpene:YP weight ratio up to 5:1.
Optimized hyper-loaded YP-terpene compositions for storage stability.
Evaluated payload release kinetics compared to existing formulations.

Main Results:

Achieved terpene loading capacity up to 5:1 terpene:YP weight ratio.
Extended payload release kinetics up to three-fold.
Demonstrated high encapsulation stability across a temperature range of -20 °C to 54 °C.

Conclusions:

Hyper-loaded YPs significantly enhance terpene delivery systems.
Increased loading capacity, stability, and sustained release offer broad application potential.
These advanced YP formulations could benefit agriculture and medicine.