Related Experiment Videos
Ketorolac tromethamine as compared with morphine sulfate for treatment of postoperative pain
Abstract:
Ketorolac tromethamine, a nonnarcotic, prostaglandin synthesis-inhibiting analgesic, was compared with morphine sulfate for relief of moderate to severe postoperative pain. The 155 patient participants received single intramuscular doses of either ketorolac, 10, 30, or 90 mg, or morphine, 6 or 12 mg, administered in a double-blind, randomized fashion. Pain scores (verbal and visual analog) were recorded at baseline and assessed at 30 minutes and then hourly to 6 hours. Pain relief was rated at the same times. Ketorolac, 90 and 30 mg, was rated significantly better than morphine, 6 mg, at each assessment interval after 1 hour. Ketorolac, 90 and 30 mg, was rated similarly to morphine, 12 mg, for the first 3 hours and better than morphine, 12 mg, 4 hours after injection. There were no serious side effects reported. The only side effect reported in more than 3% of patients was 8% somnolence with morphine. This study shows ketorolac to be a safe and effective analgesic for relief of postoperative pain.
Insights
Ketorolac tromethamine effectively manages moderate to severe postoperative pain, showing comparable or superior results to morphine. This nonnarcotic analgesic offers a safe and effective option for pain relief.
Area of Science:
- Pharmacology
- Anesthesiology
- Pain Management
Background:
- Postoperative pain management is crucial for patient recovery.
- Nonnarcotic analgesics are sought to minimize opioid-related side effects.
- Ketorolac tromethamine is a prostaglandin synthesis inhibitor with analgesic properties.
Purpose of the Study:
- To compare the efficacy and safety of ketorolac tromethamine with morphine sulfate for moderate to severe postoperative pain.
- To evaluate different dosage regimens of ketorolac and morphine.
Main Methods:
- A double-blind, randomized study involving 155 patients.
- Single intramuscular doses of ketorolac (10, 30, 90 mg) or morphine (6, 12 mg) were administered.
- Pain scores and relief were assessed hourly for 6 hours using verbal and visual analog scales.
Main Results:
- Ketorolac at 30 and 90 mg demonstrated significantly better pain relief than 6 mg morphine after 1 hour.
- Higher doses of ketorolac (30, 90 mg) showed similar efficacy to 12 mg morphine for the first 3 hours, and superior efficacy at 4 hours.
- No serious adverse events were reported; somnolence was the most common side effect (8%) with morphine.
Conclusions:
- Ketorolac tromethamine is a safe and effective analgesic for managing moderate to severe postoperative pain.
- Ketorolac offers a viable alternative to morphine, particularly at higher doses.
- Further research may explore optimal dosing and long-term safety profiles.