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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Lymphoid Cells and Tissues01:18

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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
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The Nucleolus02:55

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The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
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Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

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Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
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Long noncoding RNAs (lncRNAs) in human lymphomas.

Ali Gholami1, Khosro Farhadi1, Fatemeh Sayyadipour1

  • 1Clinical Research Development Center, Taleghani and Imam Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah 671568-5420, Iran.

Genes & Diseases
|June 10, 2022
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) are crucial in lymphoma development, impacting cell growth and survival. Their dysregulation drives lymphoma initiation and progression, offering potential clinical value.

Keywords:
ApoptosisLong non-coding RNALymphomaPrognosisProliferation

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Area of Science:

  • Hematology
  • Molecular Biology
  • Genetics

Background:

  • Lymphomas are cancers of the lymphatic system's infection-fighting cells.
  • Long non-coding RNAs (lncRNAs) are key regulators of gene expression.

Purpose of the Study:

  • To review current knowledge on lncRNAs in lymphomas.
  • To explore their molecular functions and clinical potential.

Main Methods:

  • PubMed search for English literature.
  • Keywords: Lymphoma, LncRNA, leukemia, proliferation, apoptosis, prognosis.

Main Results:

  • lncRNAs are vital in lymphoma carcinogenesis, influencing apoptosis, proliferation, invasion, and chemotherapy response.
  • lncRNA expression levels affect chemotherapy-induced apoptosis.
  • lncRNA dysregulation is linked to lymphoma initiation and progression.

Conclusions:

  • lncRNA transcription is critically related to lymphoma initiation and progression.
  • Aberrant lncRNA expression can transform normal lymphocytes into lymphoma cells.
  • lncRNAs hold potential clinical value in lymphoma management.