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Updated: Sep 20, 2025

Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons
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Calcineurin in development and disease.

Lei Chen1, Min Song1, Chunyan Yao1

  • 1Department of Blood Transfusion, First Affiliated Hospital, The Third Military Medical University (Army Medical University), Chongqing 400038, PR China.

Genes & Diseases
|June 10, 2022
PubMed
Summary
This summary is machine-generated.

Calcineurin (CaN), a calcium-dependent phosphatase, regulates cellular processes. This review highlights CaN's vital role in development and diseases like immune disorders, neurodegeneration, and cancer.

Keywords:
CalcineurinCancerCardiomyopathyDevelopmentImmune system diseaseKidney diseaseNeurodegeneration

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Area of Science:

  • Biochemistry and Molecular Biology
  • Cellular Signaling
  • Physiology

Background:

  • Calcineurin (CaN) is a calcium (Ca 2+) and calmodulin (CaM)-dependent serine/threonine phosphatase.
  • CaN activation occurs in response to elevated intracellular Ca 2+ levels.
  • Activated CaN dephosphorylates diverse substrates, including transcription factors, receptors, and ion channels.

Purpose of the Study:

  • To review the structural and functional characteristics of Calcineurin (CaN).
  • To elucidate the critical involvement of CaN in physiological development and disease pathogenesis.
  • To summarize CaN's role in immune disorders, neurodegenerative diseases, kidney disease, cardiomyopathy, and cancer.

Main Methods:

  • Literature review of existing scientific publications.
  • Analysis of structural and functional data related to Calcineurin.
  • Synthesis of information on CaN's role in various biological processes and diseases.

Main Results:

  • Calcineurin (CaN) signaling is integral to organ development.
  • CaN dysregulation is implicated in the onset and progression of numerous diseases.
  • The review consolidates evidence for CaN's multifaceted roles across different pathologies.

Conclusions:

  • Calcineurin (CaN) is a key regulator of cellular functions, essential for normal development.
  • Dysregulation of the CaN pathway contributes significantly to the pathogenesis of major diseases.
  • Targeting CaN offers potential therapeutic strategies for immune, neurological, renal, cardiac, and oncological conditions.