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A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
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Examination of New Electrocardiographic Repolarization Markers in Diabetic Patients with Noncritical Coronary Artery

Müjgan Gürler1, Mehmet İnanır2

  • 1Bolu Abant İzzet Baysal University Faculty of Medicine, Department of Internal Medicine, Bolu, Turkey.

International Journal of Clinical Practice
|June 10, 2022
PubMed

Insights

Diabetic patients with coronary artery disease (CAD) show elevated ventricular repolarization markers on ECG. These findings suggest a potential link to fatal arrhythmias, warranting further investigation in larger trials.

Area of Science:

  • Cardiology
  • Diabetology
  • Electrocardiography

Background:

  • Diabetes mellitus (DM) is a chronic disease impacting multiple organs.
  • Coronary artery disease (CAD) is a primary cause of mortality in diabetic individuals.
  • Ventricular repolarization parameters from electrocardiograms (ECG) can predict adverse outcomes.

Purpose of the Study:

  • To investigate ventricular repolarization indices in diabetic patients diagnosed with CAD.
  • To compare ECG repolarization parameters between diabetic patients with and without CAD.

Main Methods:

  • The study included 84 diabetic patients with noncritical CAD and 84 diabetic controls with normal coronary arteries.
  • Measurements included QT, QRS, JT, and Tp-e intervals, along with Tp-e/QT, Tp-e/QTc, Tp-e/JT, and Tp-e/JTc ratios.
  • Corrected intervals (QTc, JTc) and dispersion measures (QTd, QTdc) were also calculated.

Main Results:

  • Diabetic patients with noncritical CAD exhibited significantly higher heart rate, QT, QTc, QTd, QTdc, Tp-e, JT, and JTc intervals compared to controls.
  • Elevated Tp-e/QT, Tp-e/QTc, Tp-e/JT, and Tp-e/JTc ratios were observed in the diabetic CAD group.
  • These differences were statistically significant (p < 0.05 for all parameters).

Conclusions:

  • Ventricular repolarization markers are elevated in diabetic patients with CAD.
  • These ECG parameters may serve as indicators for fatal arrhythmic events in this population.
  • Further large-scale, randomized controlled trials are necessary to confirm these findings.
Abstract

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