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Prognostic Value of Lymphocyte-to-White Blood Cell Ratio for In-Hospital Mortality in Infective Endocarditis Patients
Mengying Zhang1,2, Qiuxia Ge1,2, Tengfei Qiao3
1Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
International Journal of Clinical Practice
|June 10, 2022
Summary
The lymphocyte-to-white blood cell ratio (LWR) can predict short-term outcomes in infective endocarditis (IE) patients. A higher LWR indicates a better prognosis, making it a valuable tool for identifying high-risk individuals.
Area of Science:
- Cardiology
- Infectious Diseases
- Hematology
Background:
- Infective endocarditis (IE) carries a poor prognosis.
- Predictive markers for short-term outcomes in IE are crucial.
Purpose of the Study:
- To evaluate the utility of the admission lymphocyte-to-white blood cell ratio (LWR) in predicting short-term outcomes for IE patients.
- To determine if LWR is an independent predictor of in-hospital mortality in IE.
Main Methods:
- Retrospective analysis of 147 IE patients (January 2017 - December 2019).
- Patients categorized into survivor and nonsurvivor groups.
- Univariate, multivariate, and ROC curve analyses were employed.
Main Results:
- LWR was significantly higher in survivors (0.17 ± 0.08) than nonsurvivors (0.10 ± 0.06) (P=0.001).
- Multivariate analysis confirmed LWR as an independent predictor of early death (HR: 1.755; P<0.001).
- ROC analysis showed LWR (cutoff 0.10) had an AUC of 0.750, with 70.0% sensitivity and 76.4% specificity.
Conclusions:
- The lymphocyte-to-white blood cell ratio (LWR) is a simple, inexpensive, and reliable prognostic marker for IE.
- LWR can effectively identify IE patients at high risk for in-hospital mortality.
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