Predictive Values of Coagulation Parameters to Monitor COVID-19 Patients

Area of Science:

• Medical Research
• Infectious Diseases
• Hematology

Background:

• Coronavirus disease (COVID-19) is a global health concern.
• Coagulation abnormalities are frequently observed in COVID-19 patients.
• Understanding the role of coagulation parameters in COVID-19 severity is crucial.

Purpose of the Study:

• To investigate the relationship between coagulation parameters (D-dimer, PT, INR, APTT) and COVID-19 severity.
• To assess the utility of these parameters in differentiating between SARS-CoV-2 positive and negative individuals.
• To explore the role of coagulation markers in hospitalized COVID-19 patients, including ICU admissions.

Main Methods:

• Retrospective study conducted in an Emergency Department.
• Inclusion of 289 patients with upper respiratory tract infection symptoms.
• Laboratory tests included SARS-CoV-2 PCR, D-dimer, PT, APTT, and INR.

Main Results:

• 110 patients tested PCR positive for SARS-CoV-2.
• Elevated mean levels of D-dimer, PT, and INR were found in COVID-19 positive patients.
• These coagulation parameters did not accurately differentiate between SARS-CoV-2 positive and negative groups.

Conclusions:

• D-dimer, PT, and INR levels are elevated in COVID-19 patients.
• These markers are not sufficient to accurately diagnose SARS-CoV-2 infection.
• Coagulation parameters may be important for documenting the clinical severity of hospitalized COVID-19 patients.