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Correlation Analysis between Tamoxifen and Lumbar Intervertebral Disc Degeneration: A Retrospective Case-Control
Xiangyu Li1, Ruoyu Zhao1, Samuel Rudd2
1Department of Spine Surgery, The Third Hospital of Hebei Medical University, 139 Ziqiang Road, Shijiazhuang 050051, China.
Tamoxifen (TAM) use may correlate with lumbar intervertebral disc degeneration (IVDD), particularly affecting the L1/2 and L2/3 levels. Further research is needed to confirm this association in patients with a history of breast cancer surgery.
Area of Science:
- Spine Surgery
- Oncology
- Radiology
Background:
- Tamoxifen (TAM) is a widely used medication for breast cancer treatment.
- Potential side effects of TAM on musculoskeletal health, specifically intervertebral disc degeneration (IVDD), require investigation.
Purpose of the Study:
- To explore the potential correlation between tamoxifen (TAM) usage and the incidence and severity of lumbar intervertebral disc degeneration (IVDD).
Main Methods:
- Retrospective review of 75 patients who underwent spine surgery between 2015 and 2020.
- Patients with a history of breast cancer surgery were divided into TAM and non-TAM groups.
- Lumbar IVDD was assessed using lumbar lordosis, CT density, disc height index, Modic changes, and modified Pfirrmann grading.
Main Results:
- The TAM group showed significantly lower disc height index at L1/2 and L2/3 compared to the non-TAM group.
- Higher modified Pfirrmann grading scores for L1/2 and L2/3 intervertebral discs were observed in the TAM group.
- No significant differences were found in age, BMI, vertebral CT density, or Modic changes between the groups.
Conclusions:
- Tamoxifen use may be associated with an increased risk of lumbar intervertebral disc degeneration (IVDD).
- The degeneration observed appears more pronounced at the L1/2 and L2/3 lumbar levels in patients using TAM.
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