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Cardiac involvement according to echocardiographic findings in severe coronavirus disease 2019

Marzieh Tajmirriahi1, Mehrzad Salmasi2, Forogh Soltaninejad3

  • 1Assistant Professor, Cardiac Rehabilitation Research Center, Cardiovascular Research Institute AND Department of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran.

ARYA Atherosclerosis
|June 10, 2022
PubMed

Insights

Echocardiography revealed mild to moderate left ventricular systolic dysfunction in severe COVID-19 patients, which did not significantly impact prognosis. However, elevated cardiac biomarkers predicted higher mortality in these patients.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Myocardial injury is common in COVID-19 patients, but cardiac imaging data are scarce.
  • Severe COVID-19 poses a significant global health threat with high morbidity and mortality.
  • Understanding cardiac involvement is crucial for managing severe cases.

Purpose of the Study:

  • To evaluate myocardial involvement using echocardiography in patients with severe COVID-19.
  • To assess the prevalence and severity of left ventricular systolic dysfunction (LVSD) in severe COVID-19.
  • To correlate echocardiographic findings with clinical outcomes and mortality.

Main Methods:

  • A cohort of 64 severe COVID-19 patients admitted to the ICU was studied.
  • Demographic, laboratory, and ECG data were collected.
  • Transthoracic echocardiography (TTE) was performed using a focused protocol.

Main Results:

  • Reduced left ventricular (LV) systolic function was observed in 32% of patients, mostly mild to moderate.
  • Elevated cardiac troponin I (cTn-I) was found in 60.9% of patients and associated with higher mortality (P=0.05).
  • Dynamic ST-T wave changes and new bundle branch blocks correlated with adverse outcomes (P=0.05 and P=0.02).

Conclusions:

  • New LVSD in severe COVID-19 is common but generally mild to moderate and does not significantly affect prognosis.
  • Elevated cardiac biomarkers are predictive of mortality and adverse clinical outcomes in severe COVID-19.
  • Echocardiography is a valuable tool for assessing cardiac involvement in severe COVID-19.
Abstract

Keywords:
Cardiac InvolvementCoronavirus Disease 2019Echocardiography

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