Related Experiment Video
Updated: Sep 20, 2025
09:43
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
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Diverse Roles of NETosis in the Pathogenesis of Lupus
Meiying Wang1,2, Tatsuya Ishikawa1, Yupeng Lai2
1Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, United States.
Frontiers in Immunology
|June 10, 2022
Summary
Neutrophil extracellular traps (NETs) contribute to lupus pathogenesis through autoantibody production, inflammation, and tissue damage. Targeting NETosis pathways offers a potential therapeutic strategy for treating lupus.
Area of Science:
- Immunology
- Cell Biology
- Pathology
Background:
- Neutrophil extracellular traps (NETs) are crucial for immune defense but aberrant NETosis is implicated in lupus.
- Dysregulated NET production and clearance contribute to lupus pathogenesis in humans and animals.
Approach:
- This review synthesizes evidence on the multifaceted roles of NETosis in lupus.
- It examines how NETs contribute to autoantigen release, inflammation, and tissue damage in lupus.
Key Points:
- Extruded nuclear antigens from NETs can break self-tolerance, promoting autoantibody production.
- Excessive NETs drive inflammation, renal cell cytotoxicity, and tissue damage, including capillary necrosis and podocyte loss.
- NETosis can induce endothelial-to-mesenchymal transition, fostering fibrosis through myofibroblast activation.
Conclusions:
- Aberrant NETosis plays diverse roles in lupus pathogenesis, from initial autoantibody production to advanced tissue damage.
- Current lupus treatments may inhibit NETosis, suggesting therapeutic potential.
- Targeting NETosis pathways presents a promising strategy for future lupus treatments, requiring further research to define specific roles at different disease stages.
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