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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Periodontitis and cardiovascular disease: A literature review

Alireza Rahimi1, Zohreh Afshari2

  • 1Dentistry Student, Student Research Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.

ARYA Atherosclerosis
|June 10, 2022
PubMed

Insights

Individuals with periodontitis have a higher prevalence of cardiovascular diseases (CVDs) like myocardial infarction and hypertension. Treating periodontitis may improve heart health, but further research is necessary.

Area of Science:

  • Oral Health and Cardiology
  • Systemic Disease Links

Background:

  • Cardiovascular diseases (CVDs) are a leading cause of global mortality.
  • Periodontitis is a prevalent oral condition with potential links to systemic health.
  • Shared risk factors may connect periodontitis and various CVDs, including myocardial infarction (MI), hypertension (HTN), coronary atherosclerosis (CAS), infective endocarditis (IE), heart failure (HF), arterial fibrillation (AF), and peripheral artery disease (PAD).

Purpose of the Study:

  • To systematically review existing literature on the association between heart diseases and periodontitis.
  • To assess the relationship between oral health and cardiovascular conditions.

Main Methods:

  • A comprehensive literature search was conducted across PubMed, Scopus, and Web of Science databases up to November 2020.
  • Keywords included "periodontal disease," "periodontitis," "oral health," and specific cardiovascular conditions such as "atherosclerosis," "hypertension," and "peripheral artery disease."

Main Results:

  • Periodontitis was found to be associated with MI, HTN, CAS, IE, HF, AF, and PAD.
  • Evidence suggests that periodontitis treatment could potentially improve outcomes for these cardiovascular conditions.

Conclusions:

  • Individuals with periodontitis exhibit a higher prevalence of cardiovascular diseases.
  • Further investigation is required to confirm the therapeutic benefits of periodontitis treatment on CVDs.
Abstract

Keywords:
AtherosclerosisCardiovascular DiseaseHypertensionMyocardial InfarctionPeriodontal DiseasePeriodontitisSystemic Inflammation

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