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951

Dyslipidemia and other parameters in women with pregnancy induced hypertension

Alaa Saber Shihab1, Maha Arshad Hamdi2, Abdulhadi Mohamed Jumaa2

  • 1Department of Physiology, College of Medicine, Tikrit University, Salah-Aldeen, Iraq; drnihadkhalawe@gmail.com.

Journal of Population Therapeutics and Clinical Pharmacology = Journal De La Therapeutique Des Populations Et De La Pharmacologie Clinique
|June 10, 2022
PubMed

Insights

Pregnancy-induced hypertension (PIH) is linked to altered lipid profiles and elevated inflammatory markers like interleukin-6 (IL-6) and C-reactive protein (CRP). These changes correlate with increased blood pressure in women with PIH.

Area of Science:

  • Obstetrics and Gynecology
  • Clinical Biochemistry
  • Cardiovascular Health

Background:

  • Pregnancy-induced hypertension (PIH) is associated with known alterations in lipid profiles and inflammatory markers such as interleukin-6 (IL-6) and C-reactive protein (CRP).
  • The precise causal relationships between these biochemical markers and the development or progression of PIH remain incompletely understood.

Purpose of the Study:

  • To investigate the association between serum lipid profiles, CRP, and IL-6 levels and the presence of PIH.
  • To explore potential biochemical indicators for PIH.

Main Methods:

  • A cross-sectional study involving 60 pregnant women diagnosed with PIH and 60 healthy pregnant women as controls.
  • Blood samples were analyzed for lipid profiles (triglycerides, LDL-C, HDL-C, total cholesterol, VLDL-C), CRP, and IL-6.
  • Data collected from January to April 2021 at General Salah Alden Hospital, Tikrit, Iraq.

Main Results:

  • Statistically significant differences were observed in IL-6 and CRP levels between women with PIH and the control group.
  • Aberrant lipid profiles, including triglycerides, LDL-C, HDL-C, total cholesterol, and VLDL-C, were identified in the PIH group.
  • Significant variations in these biochemical markers were noted when comparing PIH patients to healthy controls.

Conclusions:

  • The study findings indicate that women with PIH exhibit abnormal lipid profiles.
  • Elevated levels of IL-6 protein were found to be positively correlated with blood pressure in women with PIH.
  • These biochemical alterations suggest a potential role in the pathophysiology of pregnancy-induced hypertension.
Abstract

Keywords:
C- reactive protein CRPDyslipidemiaInflammatory cytokinesInterleukin-6 (IL-6)Pregnancy hypertension

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