Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peptidoglycan Synthesis01:28

Peptidoglycan Synthesis

501
Structure of PeptidoglycanPeptidoglycan is a vital structural component of the bacterial cell wall, providing mechanical strength and shape to the cell. It consists of repeating units of two sugars—N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM)—linked by β-1,4 glycosidic bonds. These sugar chains are cross-linked by short peptide chains, forming a mesh-like polymer that surrounds the bacterial plasma membrane.Cytoplasmic Phase – Precursor SynthesisPeptidoglycan...
501

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long noncoding RNA H19 in the injured dorsal root ganglion contributes to peripheral nerve injury-induced pain hypersensitivity.

Translational perioperative and pain medicine·2020
Same author

Effects of glucose metabolism pathways on nuclear and cytoplasmic maturation of pig oocytes.

Scientific reports·2020
Same author

Enhanced Delivery of Rituximab Into Brain and Lymph Nodes Using Timed-Release Nanocapsules in Non-Human Primates.

Frontiers in immunology·2020
Same author

The Brief Analysis of Peptide-combined Nanoparticle: Nanomedicine's Unique Value.

Current protein & peptide science·2020
Same author

The prognostic value of a seven-lncRNA signature in patients with esophageal squamous cell carcinoma: a lncRNA expression analysis.

Journal of translational medicine·2020
Same author

Bifidobacterium pseudolongum reduces triglycerides by modulating gut microbiota in mice fed high-fat food.

The Journal of steroid biochemistry and molecular biology·2020

Related Experiment Video

Updated: Sep 20, 2025

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
10:12

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

2.3K

A new cyclic peptide from Selaginella tamariscina.

Jing Wen1, Yuan Liu2,3, Shao-Shan Zhang2,3

  • 1College of Pharmacy, Harbin University of Commerce, Harbin 150076, China.

Journal of Asian Natural Products Research
|June 10, 2022
PubMed
Summary

A novel cyclic peptide, selapeptin B, was isolated from Selaginella tamariscina. This compound demonstrated potent cytotoxic activity against melanoma cell lines, suggesting therapeutic potential.

Keywords:
Selaginella tamariscinaSelaginellaceaecytotoxicitymoellenoside Cselapeptin B

More Related Videos

Multi-Faceted Mass Spectrometric Investigation of Neuropeptides in Callinectes sapidus
09:22

Multi-Faceted Mass Spectrometric Investigation of Neuropeptides in Callinectes sapidus

Published on: May 31, 2022

2.5K
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
07:11

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

2.8K

Related Experiment Videos

Last Updated: Sep 20, 2025

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
10:12

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

2.3K
Multi-Faceted Mass Spectrometric Investigation of Neuropeptides in Callinectes sapidus
09:22

Multi-Faceted Mass Spectrometric Investigation of Neuropeptides in Callinectes sapidus

Published on: May 31, 2022

2.5K
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
07:11

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

2.8K

Area of Science:

  • Natural Product Chemistry
  • Pharmacology
  • Medicinal Chemistry

Background:

  • Selaginella tamariscina is a plant species known for its diverse secondary metabolites.
  • Natural products are a rich source of potential therapeutic agents.
  • Melanoma remains a significant health concern, necessitating novel treatment strategies.

Purpose of the Study:

  • To isolate and characterize bioactive compounds from Selaginella tamariscina.
  • To evaluate the cytotoxic potential of isolated compounds against cancer cell lines.
  • To identify novel anti-melanoma agents from natural sources.

Main Methods:

  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation using spectroscopic methods (1D, 2D NMR, HRESIMS).
  • Cytotoxicity evaluation using the MTT assay against B16F10, MDA-MB-231, and MDA-MB-468 cell lines.

Main Results:

  • A new cyclic peptide, selapeptin B (1), and a known nor-lignan glycoside, moellenoside C (2), were successfully isolated.
  • Selapeptin B (1) exhibited potent cytotoxic activity against the B16F10 melanoma cell line.
  • Moellenoside C (2) showed moderate activity against the tested cell lines.

Conclusions:

  • Selaginella tamariscina is a valuable source of bioactive cyclic peptides.
  • Selapeptin B represents a promising lead compound for the development of anti-melanoma therapies.
  • Further investigation into the mechanism of action of selapeptin B is warranted.