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Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
Published on: September 19, 2022
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A new cyclic peptide from Selaginella tamariscina
Jing Wen1, Yuan Liu2,3, Shao-Shan Zhang2,3
1College of Pharmacy, Harbin University of Commerce, Harbin 150076, China.
Journal of Asian Natural Products Research
|June 10, 2022
Abstract:
A new cyclic peptide selapeptin B (1), together with one known nor-lignan glycoside moellenoside C (2), was isolated from Selaginella tamariscina. The structures of 1 and 2 were elucidated on the basis of chemical and spectral analysis, including 1D, 2D NMR analyses and HRESIMS. Two compounds were evaluated for cytotoxic activities against B16F10, MDA-MB-231, and MDA-MB-468 cell lines by MTT assay. Compound 1 showed the potent activity against B16F10 melanoma cell lines.

