Related Experiment Video
Updated: Sep 20, 2025
05:31
Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
Published on: May 16, 2025
322
Sex differences in acute type A aortic dissection: a systematic review and meta-analysis
Nicholas M Fialka1, Sabin J Bozso2, Ryaan El-Andari1
1Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
The Journal of Cardiovascular Surgery
|June 10, 2022
Summary
Early mortality after acute type A aortic dissection (ATAAD) repair is similar for males and females. However, long-term outcomes favor males, with differences potentially linked to sex-specific risk factors and treatment choices.
Area of Science:
- Cardiovascular Surgery
- Thoracic Surgery
- Aortic Disease
Background:
- Acute type A aortic dissection (ATAAD) is a life-threatening condition requiring prompt surgical intervention.
- Understanding sex-based differences in ATAAD outcomes is crucial for optimizing patient care.
Purpose of the Study:
- To compare outcomes of acute type A aortic dissection (ATAAD) repair between males and females.
- To identify potential sex-specific risk factors influencing ATAAD repair results.
Main Methods:
- Systematic literature search of PubMed, Medline, and Web of Science (2000-2021).
- Inclusion of 16 studies after screening 2405 articles.
- Meta-analysis of compiled data to compare outcomes between sexes.
Main Results:
- No significant differences in operative, in-hospital, or 30-day mortality between males and females.
- Males demonstrated significantly lower 5-year mortality rates.
- Males had higher rates of acute renal failure and reoperation, while stroke and ischemia rates were similar.
Conclusions:
- Early mortality after ATAAD repair is comparable between sexes.
- Late outcomes, specifically 5-year survival, favor males.
- Sex-specific preoperative presentations and procedural choices may explain outcome disparities, necessitating consideration of these factors in treatment decisions.
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