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Risk factors associated with bacteremia in COVID-19 patients admitted to intensive care unit: a retrospective
Cecilia Bonazzetti1, Matteo Rinaldi2, Andrea Giacomelli3
1Infectious Diseases Unit IRCCS, Policlinico Sant'Orsola, Department Medical Surgical Science, University of Bologna, Bologna, Italy. cecilia.bonazzetti@gmail.com.
Purpose:
This multicenter observational study was done to evaluate risk factors related to the development of BSI in patients admitted to ICU for COVID-19.
Methods:
All patients with COVID-19 admitted in two COVID-19 dedicated ICUs in two different hospital between 02-2020 and 02-2021 were recruited.
Result:
537 patients were included of whom 265 (49.3%) experienced at least one BSI. Patients who developed bacteremia had a higher SOFA score [10 (8-12) vs 9 (7-10), p < 0.001], had been intubated more frequently [95.8% vs 75%, p < 0.001] and for a median longer time [16 days (9-25) vs 8 days (5-14), p < 0.001]. Patients with BSI had a median longer ICU stay [18 days (12-31.5) vs 9 days (5-15), p < 0.001] and higher mortality [54% vs 42.3%, p < 0.001] than those who did not develop it. Development of BSI resulted in a higher SOFA score [aHR 1.08 (95% CI 1.03-1.12)] and a higher Charlson score [csAHR 1.15 (95% CI 1.05-1.25)].
Conclusion:
A high SOFA score and a high Charlson score resulted associated with BSI's development. Conversely, immunosuppressive therapy like steroids and tocilizumab, has no role in increasing the risk of bacteremia.
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