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Related Experiment Video

Updated: Sep 20, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Osteocalcin association with vascular function in chronic kidney disease.

Xinru Guo1,2, Yisha Li2, Yena Zhou1,2

  • 1School of Medicine, Nankai University, Tianjin, China.

Journal of Clinical Hypertension (Greenwich, Conn.)
|June 10, 2022
PubMed
Summary

Serum osteocalcin (OCN) levels impact vascular health in chronic kidney disease (CKD) patients. Lower OCN is linked to endothelial dysfunction, while higher OCN correlates with increased arterial stiffness but improved endothelial function in specific CKD subgroups.

Keywords:
Endo-PAT 2000arterial stiffnessendothelial dysfunctionosteocalcinvascular function

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Area of Science:

  • Endocrinology
  • Nephrology
  • Cardiovascular Medicine

Background:

  • Osteocalcin (OCN) is a vitamin K-dependent hormone influencing energy metabolism and vascular calcification.
  • The precise relationship between serum OCN and vascular function in chronic kidney disease (CKD) patients remains unclear.
  • Vascular dysfunction is a significant complication in CKD patients, contributing to cardiovascular morbidity and mortality.

Purpose of the Study:

  • To investigate the association between serum OCN levels and vascular function in pre-dialysis CKD patients.
  • To evaluate vascular function using reactive hyperemia index (RHI) and augmentation index (AIx) as measured by the Endo-PAT 2000 device.
  • To explore potential differential effects of OCN on endothelial function and arterial stiffness across various CKD patient subgroups.

Main Methods:

  • Cross-sectional analysis of 256 pre-dialysis CKD patients who underwent serum OCN measurement and Endo-PAT 2000 testing.
  • Patients were categorized into groups based on RHI values (<1.67 for endothelial dysfunction).
  • Multivariate logistic and linear regression models, along with subgroup analyses, were employed to assess the association between OCN and vascular parameters (RHI and AIx).

Main Results:

  • After adjusting for confounders, lower serum OCN levels were significantly associated with endothelial dysfunction (OR: 0.794; P=.006).
  • Conversely, higher serum OCN levels were correlated with increased arterial stiffness (standardized β: 0.174; P=.003).
  • Subgroup analyses revealed that higher OCN was linked to greater arterial stiffness but better endothelial function in younger patients, males, those with hypertension or diabetes, and individuals in earlier stages of CKD.

Conclusions:

  • Serum OCN demonstrates a complex correlation with vascular function in CKD patients.
  • Elevated OCN may be beneficial for endothelial function while simultaneously contributing to arterial stiffness.
  • These findings highlight the nuanced role of OCN in CKD vascular complications and suggest potential therapeutic targets.