Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

284
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
284
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

170
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
170
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

325
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
325
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

226
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
226
Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

155
Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
155
Esophageal Perforation-I: Introduction01:22

Esophageal Perforation-I: Introduction

183
Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
183

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Short, not skinny: The distinct sarcopenia phenotype of pediatric primary sclerosing cholangitis-inflammatory bowel disease.

Journal of pediatric gastroenterology and nutrition·2026
Same author

Alternative Therapeutic Approaches in the Management of Gastroparesis: A Systematic Review.

Diseases (Basel, Switzerland)·2026
Same author

Kidney pathology findings in pediatric patients with kidney injury and inflammatory bowel disease: a case series.

Pediatric nephrology (Berlin, Germany)·2026
Same author

Development of a lifelong core outcome set for oesophageal atresia ± tracheoesophageal fistula: the OCELOT study.

BMJ open·2026
Same author

Rome V Pediatric Upper Gastrointestinal Disorders of Gut-Brain Interaction.

Gastroenterology·2026
Same author

The Role of Vitamin D in Eosinophilic Esophagitis in Children.

Journal of paediatrics and child health·2025

Related Experiment Video

Updated: Sep 20, 2025

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
10:15

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

7.1K

Infectious Esophagitis in Children.

Jonathan E M O'Donnell1,2, Usha Krishnan1,2

  • 1From the Department of Pediatric Gastroenterology, Sydney Children's Hospital, Randwick, NSW, Australia.

Journal of Pediatric Gastroenterology and Nutrition
|June 10, 2022
PubMed
Summary
This summary is machine-generated.

Infectious esophagitis, caused by Candida, Herpes simplex virus (HSV), and cytomegalovirus (CMV), is a significant cause of dysphagia. Impaired immunity, esophageal dysmotility, and altered esophageal homeostasis are key risk factors.

More Related Videos

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

925
Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

534

Related Experiment Videos

Last Updated: Sep 20, 2025

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
10:15

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

7.1K
Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

925
Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

534

Area of Science:

  • Gastroenterology and Infectious Diseases
  • Esophageal Pathophysiology

Background:

  • Infectious esophagitis is the third leading cause of esophagitis.
  • Common pathogens include Candida, Herpes simplex virus (HSV), and cytomegalovirus (CMV).
  • Risk factors include impaired immunity, esophageal dysmotility, and disruptions in esophageal homeostasis.

Purpose of the Study:

  • To highlight the importance of considering infectious esophagitis in patients with dysphagia and odynophagia.
  • To review the common causative organisms and risk factors for infectious esophagitis.

Main Methods:

  • Literature review and synthesis of existing knowledge on infectious esophagitis.
  • Analysis of etiological agents and pathogenetic mechanisms.

Main Results:

  • Candida, HSV, and CMV are the most frequent causes of infectious esophagitis.
  • Impaired local or systemic immunity is a recognized risk factor.
  • Esophageal dysmotility and altered esophageal homeostasis are likely additional contributors.

Conclusions:

  • Infectious esophagitis is a crucial differential diagnosis for dysphagia and odynophagia.
  • Understanding the role of immune status, esophageal motility, and homeostasis is vital for pathogenesis.
  • Further research into these factors may improve diagnosis and treatment strategies.