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The C-seal: A Biofragmentable Drain Protecting the Stapled Colorectal Anastomosis from Leakage
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Do Antiseptic Coated Sutures Reduce Colo-Colonic Anastomotic Leaks?
Christiaan F Elsenbroek1, Martin Brand1
1Department of Surgery, University of Pretoria, Pretoria, South Africa.
Surgical Innovation
|June 10, 2022
Summary
Triclosan-coated polydioxanone sutures (PDS) did not significantly reduce colorectal anastomotic leaks in a rabbit model. The antiseptic-coated sutures demonstrated comparable safety and efficacy to uncoated PDS for bowel anastomosis.
Area of Science:
- Surgical Innovation
- Biomaterials Science
- Gastrointestinal Surgery
Background:
- Colorectal anastomotic leaks are a major surgical complication.
- Existing interventions show limited success in reducing leaks.
- Antiseptic-coated sutures have not been evaluated for bowel anastomoses.
Purpose of the Study:
- To investigate if triclosan-impregnated polydioxanone suture material (PDS) reduces colorectal anastomotic leaks.
- To compare the safety and efficacy of triclosan-coated PDS versus uncoated PDS in bowel anastomosis.
Main Methods:
- A rabbit colo-colonic anastomotic model was utilized.
- Tensile strength and local inflammatory response were compared between triclosan-coated PDS and uncoated PDS.
Main Results:
- Four out of 42 anastomoses (9.5%) resulted in leaks.
- No statistically significant differences were observed in leak pressures, bowel wall inflammation, or fibrosis between the two suture groups (P = .11; .813; .658).
Conclusions:
- Triclosan-coated PDS is as safe as uncoated PDS for performing colo-colonic anastomosis in an animal model.
- Further research may be needed to explore other antiseptic coatings or suture materials.
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