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High-Throughput In Vitro Assay using Patient-Derived Tumor Organoids
Published on: June 14, 2021
A comprehensive insight into the antineoplastic activities and molecular mechanisms of deoxypodophyllotoxin: Recent
Sayeh Mottaghi1, Hassan Abbaszadeh2
1Department of Pediatrics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Abstract:
Lignans constitute an important group of polyphenols, which have been demonstrated to potently suppress cancer cell proliferation. Numerous in vitro and in vivo studies indicate that deoxypodophyllotoxin as a natural lignan possesses potent anticancer activities against various types of human cancer. The purpose of current review is to provide the reader with the latest findings in understanding the anticancer effects and molecular mechanisms of deoxypodophyllotoxin. This review comprehensively describes the influence of deoxypodophyllotoxin on signaling cascades and molecular targets implicated in cancer cell proliferation and invasion. A number of various signaling molecules and pathways, including apoptosis, necroptosis, cell cycle, angiogenesis, vascular disruption, ROS, MMPs, glycolysis, and microtubules as well as NF-κB, PI3K/Akt/mTOR, and MAPK cascades have been reported to be responsible for the anticancer activities of deoxypodophyllotoxin. The results of present review suggest that the cyclolignan deoxypodophyllotoxin can be developed as a novel and potent anticancer agent, especially as an alternative option for treatment of resistant tumors to chemotherapy.
Insights
Deoxypodophyllotoxin, a natural lignan, shows potent anticancer activity by affecting multiple cancer cell pathways. This compound shows promise as a novel agent for treating chemotherapy-resistant tumors.
Area of Science:
- Natural Products Chemistry
- Molecular Pharmacology
- Cancer Biology
Background:
- Lignans are polyphenols with demonstrated anticancer properties.
- Deoxypodophyllotoxin, a natural lignan, exhibits significant anticancer effects against various human cancers in vitro and in vivo.
Purpose of the Study:
- To review the latest findings on the anticancer effects of deoxypodophyllotoxin.
- To elucidate the molecular mechanisms underlying its anti-cancer activities.
Main Methods:
- Comprehensive literature review of in vitro and in vivo studies.
- Analysis of signaling cascades and molecular targets affected by deoxypodophyllotoxin.
Main Results:
- Deoxypodophyllotoxin influences apoptosis, necroptosis, cell cycle, angiogenesis, and vascular disruption.
- It modulates reactive oxygen species (ROS), matrix metalloproteinases (MMPs), glycolysis, and microtubule dynamics.
- Key signaling pathways like NF-κB, PI3K/Akt/mTOR, and MAPK are implicated in its anticancer effects.
Conclusions:
- Deoxypodophyllotoxin demonstrates potent anticancer activities through diverse molecular mechanisms.
- This cyclolignan holds potential as a novel therapeutic agent, particularly for drug-resistant cancers.
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