Related Experiment Video
Updated: Sep 20, 2025
05:23
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
19.7K
[Gallstone complications in sickle cell patients].
E Rambaud1, B Ranque1, J Pouchot1
1Centre de référence des syndromes drépanocytaires majeurs, thalassémie et autres maladies des globules rouges et de l'érythropoïèse, service de médecine interne, université Paris-Cité et hôpital européen Georges-Pompidou (AP-HP), 20, rue Leblanc, 75015 Paris, France.
La Revue De Medecine Interne
|June 10, 2022
Summary
Sickle cell disease patients undergoing cholecystectomy face risks. Prophylactic preoperative transfusion is advised for those with recent complications or emergency surgery, balancing transfusion benefits against risks.
Area of Science:
- Hematology
- Surgical Oncology
Background:
- Chronic hemolysis in sickle cell disease (SCD) patients leads to gallstones and biliary complications.
- Elective cholecystectomy is recommended for SCD patients with gallstones to prevent complications.
Purpose of the Study:
- To evaluate the risks and benefits of preoperative transfusion in SCD patients undergoing cholecystectomy.
- To establish guidelines for transfusion decisions in this patient population.
Main Methods:
- Review of existing studies on preoperative transfusion in SCD patients.
- Analysis of complication rates and transfusion-related risks (alloimmunization, delayed hemolysis).
Main Results:
- Surgery, especially abdominal, increases vaso-occlusive complication risk, including acute chest syndrome.
- Preoperative transfusion can reduce postoperative complications but carries risks.
- Transfusion-sparing strategies are gaining traction due to these risks.
Conclusions:
- Transfusion decisions for cholecystectomy in SCD patients require case-by-case risk-benefit assessment by specialists.
- Prophylactic transfusion is justified for patients with recent vaso-occlusive crisis/acute chest syndrome or those in emergency settings.
Keywords:
Acute chest syndromeAllo- immunisationAlloimmunizationCholecystectomyCholécystectomieDrépanocytoseSickle cell diseaseSyndrome thoracique aiguTransfusionVaso-occlusive crisisMore Related Videos
Related Concept Videos
01:26Diseases of the Liver and Gallbladder
1.0K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.0K
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
348
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
348
01:24Hemodialysis II: Procedure and Complications
148
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
148
01:25Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
113
Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
113
01:17Chronic Bowel Disorders: Introduction
545
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
545
01:24Chronic Kidney Disease II: Clinical Manifestations
110
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
110