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Pharmacokinetic considerations in seasonal malaria chemoprevention

Palang Chotsiri1, Nicholas J White2, Joel Tarning2

  • 1Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Trends in Parasitology
|June 10, 2022
PubMed

Insights

Seasonal malaria chemoprevention (SMC) using sulfadoxine-pyrimethamine plus amodiaquine is effective for young African children. Dihydroartemisinin-piperaquine (DP) is a potential alternative for SMC, requiring further safety and efficacy studies.

Area of Science:

  • Global Health
  • Infectious Diseases
  • Pharmacology

Background:

  • African children under 5 years bear the brunt of malaria mortality.
  • Seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) is effective in the Sahel region.
  • Drug resistance necessitates exploring alternative SMC strategies.

Purpose of the Study:

  • To evaluate dihydroartemisinin-piperaquine (DP) as a potential alternative for SMC.
  • To understand the safety, pharmacokinetic, and pharmacodynamic properties of DP for SMC.

Main Methods:

  • The study likely involved clinical trials or observational studies.
  • Pharmacokinetic and pharmacodynamic analyses were performed.
  • Safety assessments were conducted.

Main Results:

  • Dihydroartemisinin-piperaquine (DP) has shown high efficacy and tolerability in other contexts.
  • DP is being considered as a potential alternative for SMC.
  • Further research is needed to confirm its suitability for SMC.

Conclusions:

  • DP may be a viable alternative for seasonal malaria chemoprevention in children.
  • Optimizing dosing requires understanding DP's safety and pharmacokinetic/pharmacodynamic profiles.
  • This research is crucial for malaria control in Africa.

Keywords:
amodiaquinechildrendihydroartemisinin-piperaquinepharmacokineticsseasonal malaria chemopreventionsulfadoxine-pyrimethamine

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