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A normal pattern of mitral inflow predicts a better prognosis following cardiovascular events in early advanced-age

Tomoyuki Watanabe1, Masumi Iwai-Takano2,3,4, Hiromi Saitoh5,6

  • 1Division of Cardiology and Internal Medicine, Health Co-op Watari Hospital, Fukushima, Japan.

Scientific Reports
|June 10, 2022
PubMed

Insights

A normal mitral inflow pattern in early advanced-age individuals predicts a better cardiovascular prognosis. This finding suggests mitral inflow pattern is a valuable indicator for predicting outcomes after cardiovascular events in this age group.

Area of Science:

  • Cardiology
  • Echocardiography
  • Geriatric Medicine

Background:

  • Mitral inflow patterns typically change with aging, progressing from normal to abnormal relaxation.
  • However, some individuals in early advanced age maintain a normal mitral inflow pattern.
  • The prognostic significance of this preserved normal pattern in early advanced-age patients is not well understood.

Purpose of the Study:

  • To investigate whether a normal mitral inflow pattern predicts a better prognosis following cardiovascular (CV) events in early advanced-age patients (aged 60-65 years).

Main Methods:

  • Enrolled 425 patients aged 60-65 years with an E/A ratio between 0.6 and 1.5.
  • Classified patients into a normal pattern group (E/A ≥ 1.0) and an abnormal relaxation pattern group (E/A < 1.0).
  • Evaluated the relationship between mitral inflow patterns and subsequent CV events using multivariate regression and Kaplan-Meier analysis over a 4.9 ± 1.8-year follow-up.

Main Results:

  • The normal inflow pattern was associated with lower odds of elevated body mass index (BMI), hypertension, and heart rate.
  • During follow-up, the adjusted hazard ratio for CV events was significantly lower in the normal pattern group (HR: 0.119).
  • Kaplan-Meier analysis revealed a higher event-free rate in the normal pattern group compared to the abnormal relaxation pattern group (p=0.0292).

Conclusions:

  • A normal mitral inflow pattern in early advanced-age patients is a significant predictor of a better prognosis following cardiovascular events.
  • Preserved normal mitral inflow may indicate better cardiovascular resilience in this demographic.
  • Echocardiographic assessment of mitral inflow patterns can aid in risk stratification for older adults.

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