Microphysiological Systems Evaluation: Experience of TEX-VAL Tissue Chip Testing Consortium
Ivan Rusyn1, Courtney Sakolish1, Yuki Kato1
1Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas 77843, USA.
Summary
Microphysiological systems (MPS) show promise for chemical testing, but practical challenges remain. Successful implementation hinges on optimizing cells, reagents, and staff expertise, not just the devices themselves.
Area of Science:
- Toxicology
- Biotechnology
- In vitro testing
Background:
- Microphysiological systems (MPS) are miniature devices designed to mimic human physiology on a chip.
- High expectations exist for MPS adoption in chemical testing, yet widespread use is hindered by cost and utility uncertainties.
Purpose of the Study:
- To detail the experiences of a public-private collaboration testing diverse MPS.
- To present practical considerations for using MPS in decision-making for chemical safety assessments.
Main Methods:
- Evaluation of diverse microphysiological systems through a public-private partnership.
- Analysis of practical challenges and critical success factors for MPS implementation.
Main Results:
- Extensive on-site optimization and specialized equipment are necessary for MPS use.
- Success in MPS applications is primarily determined by cell quality, reagents, and technical staff expertise.
- Challenges include extrapolating results to human exposures, replicating whole organs, and ensuring long-term functionality.
Conclusions:
- Achieving a full rodent- or human-equivalent model with MPS is unlikely in the near future.
- A gradual incorporation of MPS into tiered safety assessment approaches, with building consensus, is the recommended path for adoption.
