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Cortico-cognition coupling in treatment resistant schizophrenia
Warda T Syeda1, Cassandra M J Wannan1, Antonia H Merritt1
1Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia.
Neuroimage. Clinical
|June 11, 2022
Summary
This study used multiblock partial least squares correlation (MB-PLS-C) to find brain structure and cognitive patterns in schizophrenia. A unique pattern involving frontal and temporal lobes was identified in treatment-resistant schizophrenia (TRS) patients.
Area of Science:
- Neuroscience
- Psychiatry
- Medical Imaging
Background:
- Schizophrenia is linked to brain structural changes and cognitive deficits, but their relationship is unclear.
- Treatment-resistant schizophrenia (TRS) presents unique challenges in understanding these associations.
- Investigating multivariate cortico-cognitive patterns is crucial for understanding schizophrenia's complexity.
Purpose of the Study:
- To investigate multivariate cortico-cognitive patterns in patients with treatment-resistant schizophrenia (TRS) and healthy controls (HC).
- To identify group-specific patterns of brain structure-cognition coupling using a novel MB-PLS-C technique.
- To explore potential brain structural-cognitive signatures for TRS.
Main Methods:
- Employed multiblock partial least squares correlation (MB-PLS-C) on structural MRI data and cognitive assessments (CANTAB).
- Analyzed brain region volumes and cognitive variables from 41 TRS patients and 45 HC.
- Conducted supplementary three-group analyses including 23 non-affected relatives (NAR).
Main Results:
- TRS patients exhibited cognitive impairments and reduced cortical volumes in 12 regions.
- MB-PLS-C identified two significant latent variables (LVs) explaining over 90% of variance.
- LV2, specific to TRS, revealed a differential cortico-cognitive pattern involving frontal/temporal lobes and specific cognitive tasks (PAL, IED).
Conclusions:
- MB-PLS-C successfully identified multivariate brain structural-cognitive patterns.
- These patterns may serve as a potential signature for treatment-resistant schizophrenia.
- Non-affected relatives' patterns more closely resembled healthy controls than TRS patients.
Keywords:
Brain structureCognitionMRIPartial least squares correlationTreatment-resistant schizophreniaMore Related Videos
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