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Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
Published on: September 25, 2019
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Strategic infarct location for post-stroke seizure.
Chien-Chen Chou1, Yen-Cheng Shih1, Hsu-Huai Chiu2
1Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang Ming Chiao Tung University College of Medicine, Taipei, Taiwan; Brain Research Center, National Yang-Ming University, Taipei, Taiwan.
Neuroimage. Clinical
|June 11, 2022
Summary
The location of brain infarction significantly influences the development of post-stroke seizures (PSS). Specific brain regions are associated with early or late PSS, aiding risk assessment after stroke.
Area of Science:
- Neurology
- Neuroscience
- Radiology
Background:
- Post-stroke seizures (PSS) negatively impact functional recovery.
- Risk factors for PSS are known, but the link between infarction location and PSS is unclear.
Purpose of the Study:
- To investigate the relationship between cerebral infarction location and the occurrence of post-stroke seizures (PSS).
- To identify specific brain regions associated with early and late PSS after ischemic stroke.
Main Methods:
- Compared brain MRIs of 66 PSS patients (31 early, 35 late) with 66 non-PSS patients using voxel- and volumetric-based analyses.
- Analyzed infarct maps to identify 'hot spots' in PSS versus non-PSS groups.
Main Results:
- The PSS group showed infarction 'hot spots' in the left central region, left superior parietal lobule, and right frontal operculum.
- Infarction volume was larger in the PSS group, though not significantly.
- Distinct brain region associations were found for early-PSS and late-PSS.
Conclusions:
- Cerebral infarction location is significantly associated with PSS development.
- Specific brain regions are linked to early or late PSS, suggesting location aids in risk stratification.
- Infarction mapping may help clinicians assess PSS risk at different post-stroke stages.
