Tyraminergic corollary discharge filters reafferent perception in a chemosensory neuron

Interpreting sensory information requires its integration with the current behavior of the animal. However, how motor-related circuits influence sensory information processing is incompletely understood. Here, we report that current locomotor state directly modulates the activity of BAG CO₂ sensory neurons in Caenorhabditis elegans. By recording neuronal activity in animals freely navigating CO₂ landscapes, we found that during reverse crawling states, BAG activity is suppressed by tyraminergic corollary discharge signaling. We provide genetic evidence that tyramine released from the RIM reversal interneurons extrasynaptically activates the inhibitory chloride channel LGC-55 in BAG. Disrupting this pathway genetically leads to excessive behavioral responses to CO₂ stimuli. Moreover, we find that LGC-55 signaling cancels out perception of self-produced CO₂ and O₂ stimuli when animals reverse into their own gas plume in ethologically relevant aqueous environments. Our results show that sensorimotor integration involves corollary discharge signals directly modulating chemosensory neurons.