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Updated: Sep 20, 2025

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

Testing a cascade model linking prenatal inflammation to child executive function.

Marie Camerota¹, Amanda C Wylie², Jessica Goldblum²

¹Frank Porter Graham Child Development Institute, University of North Carolina at Chapel Hill, United States.

Behavioural Brain Research

|June 11, 2022

Summary

This summary is machine-generated.

Prenatal inflammation, indicated by elevated C-reactive protein (CRP), IL-6, and TNF-α, is linked to poorer infant cognitive ability. This inflammation may indirectly impact preschool executive function through early cognitive development.

Keywords:

Childhood Executive function Infancy Inflammation Neurodevelopment Pregnancy

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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Area of Science:

Neuroscience
Developmental Psychology
Immunology

Background:

Prenatal inflammation is an emerging risk factor for adverse infant health and neurodevelopment.
Long-term effects of prenatal inflammation exposure on child development require further investigation.

Purpose of the Study:

To examine the associations between maternal inflammation during pregnancy and infant neurodevelopmental markers.
To investigate the relationship between prenatal inflammation and preschool executive function (EF).

Main Methods:

Longitudinal study of 40 African American mother-infant dyads.
Maternal plasma levels of CRP, IL-6, and TNF-α measured in the third trimester.
Infant neurodevelopment assessed at 6 months (cognitive ability, negative affect, sleep quality).
Preschool EF assessed at 4 years of age.

Main Results:

Elevated maternal CRP, IL-6, and TNF-α levels correlated with lower infant general cognitive ability.
No direct association found between prenatal inflammation and preschool EF.
An indirect relationship observed between IL-6 and preschool EF mediated by infant cognitive ability.

Conclusions:

Prenatal inflammation may have sustained, cascading effects on child neurodevelopment.
Findings highlight potential long-term implications for neurodevelopmental outcomes in children exposed to prenatal inflammation.
The study underscores the importance of considering maternal health during pregnancy for child developmental trajectories.