Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Retina01:32

The Retina

70.7K
The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
70.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human retinal organoid model of disease-relevant photoreceptor cell death amenable to drug screening.

Cell death & disease·2026
Same author

FPR2 at the crossroads of inflammation and repair in the eye.

Drug discovery today·2025
Same author

Developmental wave of programmed ganglion cell death in human retinal organoids.

bioRxiv : the preprint server for biology·2025
Same author

Advances in immunomodulation for organ transplantation: The role of the Annexin A1/FPR axis.

Clinics (Sao Paulo, Brazil)·2025
Same author

Photoreceptor deficits appear at eye opening in Rs1 mutant mouse models of X-linked retinoschisis.

Experimental eye research·2024
Same author

From 2D slices to a 3D model: Training students in digital microanatomy analysis techniques through a 3D printed neuron project.

Anatomical sciences education·2024

Related Experiment Video

Updated: Sep 20, 2025

Whole-mount Retinal Organoid Visualization with Cellular Resolution
09:20

Whole-mount Retinal Organoid Visualization with Cellular Resolution

Published on: June 20, 2025

645

Retinal organoid light responsivity: current status and future opportunities.

Jessica R Onyak1, M Natalia Vergara2, Jordan M Renna1

  • 1Department of Biology, The University of Akron, Akron, Ohio.

Translational Research : the Journal of Laboratory and Clinical Medicine
|June 11, 2022
PubMed
Summary

Human retinal organoids generated from pluripotent stem cells offer new avenues for studying retinal diseases. This review examines their light-evoked responses and future therapeutic potential.

More Related Videos

Author Spotlight: Analyzing the Synaptic Ultrastructure in Mature Retinal Organoids Using TEM
05:43

Author Spotlight: Analyzing the Synaptic Ultrastructure in Mature Retinal Organoids Using TEM

Published on: June 7, 2024

1.1K
Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells
09:47

Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells

Published on: December 9, 2022

3.7K

Related Experiment Videos

Last Updated: Sep 20, 2025

Whole-mount Retinal Organoid Visualization with Cellular Resolution
09:20

Whole-mount Retinal Organoid Visualization with Cellular Resolution

Published on: June 20, 2025

645
Author Spotlight: Analyzing the Synaptic Ultrastructure in Mature Retinal Organoids Using TEM
05:43

Author Spotlight: Analyzing the Synaptic Ultrastructure in Mature Retinal Organoids Using TEM

Published on: June 7, 2024

1.1K
Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells
09:47

Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells

Published on: December 9, 2022

3.7K

Area of Science:

  • Stem cell biology and regenerative medicine.
  • Neuroscience and ophthalmology research.

Background:

  • Pluripotent stem cells enable in vitro generation of human retinal organoids.
  • These organoids mimic native retinal structure and cellular composition.
  • Mature retinal organoids exhibit light-evoked responses.

Purpose of the Study:

  • To review the current understanding of human retinal organoid function.
  • To discuss technologies for assessing functional properties.
  • To identify challenges and opportunities in the field.

Main Methods:

  • Literature review of studies on retinal organoid function.
  • Analysis of technologies for functional assessment (e.g., electrophysiology, calcium imaging).
  • Evaluation of light-evoked responsivity across retinal cell types and layers.

Main Results:

  • Retinal organoids demonstrate light-evoked responses, indicating functional maturity.
  • Data on cell-type-specific and layer-specific responsivity remain limited.
  • Existing technologies allow for functional assessment but have limitations.

Conclusions:

  • Human retinal organoids are valuable models for retinal degenerative diseases.
  • Further research is needed to comprehensively characterize their functional properties.
  • Advancements in functional assessment technologies will enhance their utility.