Hypersensitivity reaction following chloramphenicol administration in a patient with typhoid fever

Hypersensitivity reactions due to chloramphenicol are rarely reported in the literature. We present a case report of a patient with typhoid fever who experienced a hypersensitivity reaction subsequent to the infusion of chloramphenicol sodium succinate. The patient had previously reacted similarly to ampicillin infusion. A brief review of reported cases of chloramphenicol hypersensitivity in the English-language literature, as well as possible alternative explanations in this case, are provided.