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Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
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Renewal of Intestinal Stem Cells01:23

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
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Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Introduction
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Related Experiment Video

Updated: Sep 20, 2025

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
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Hirschsprung disease outcomes.

Scott S Short1, Megan M Durham2, Michael D Rollins1

  • 1Division of Pediatric Surgery, Department of Surgery, University of Utah School of Medicine, 100N. Mario Capecchi Drive, Suite 3800, Salt Lake City, UT 84113, United States.

Seminars in Pediatric Surgery
|June 11, 2022
PubMed
Summary
This summary is machine-generated.

Hirschsprung disease (HD) management has varied outcomes. Standardized post-operative care and follow-up pathways are needed for better interpretation of results and improved patient support.

Keywords:
EnterocolitisHirschsprung diseaseOutcomeQuality of life

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Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Developmental Pediatrics

Background:

  • Hirschsprung disease (HD) presents complex surgical and medical challenges.
  • Patient outcomes vary based on age and neurodevelopmental status, with common issues like constipation and fecal incontinence.
  • Current outcome measures are difficult to interpret due to a lack of standardized post-operative bowel management and follow-up protocols.

Purpose of the Study:

  • To highlight the variability in health and social outcomes for Hirschsprung disease patients.
  • To identify the need for universally accepted post-operative care pathways and follow-up protocols.
  • To emphasize the importance of multidisciplinary care and collaborations in improving HD patient outcomes.

Main Methods:

  • Review of existing literature and clinical observations regarding Hirschsprung disease outcomes.
  • Analysis of factors influencing patient outcomes, including age at procedure and procedure type.
  • Discussion of the role of multidisciplinary care teams and consortia in addressing knowledge gaps.

Main Results:

  • Long-term outcomes for most Hirschsprung disease patients are generally good, despite persistent bowel issues.
  • Lack of consensus on optimal post-operative management and follow-up hinders clear outcome interpretation.
  • Age at surgery and procedure type are factors influencing outcomes but lack universal agreement.

Conclusions:

  • Standardized pathways for post-operative bowel management and follow-up are crucial for interpreting Hirschsprung disease outcomes.
  • Enhanced support for pediatric patients, especially in resource-limited settings and during transition to adult care, is necessary.
  • Multidisciplinary collaborations are vital for advancing the understanding and management of Hirschsprung disease, ultimately improving patient care and outcomes.