Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

74.4K
Overview
74.4K
Tissue Transplantation01:24

Tissue Transplantation

530
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
530
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

1.2K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
1.2K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

7.4K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
7.4K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

509
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
509
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

6.0K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
6.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Self-Reported Flourishing Among U.S. Surgeons: A National Physician Survey.

Journal of the American College of Surgeons·2026
Same author

Pathologic evaluation of pig kidney and heart xenografts: 2024 recommendations from the Banff Xenotransplantation Pathology Working Group.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

Selective impact on regulatory T cells with sustained functional phenotypes by the interleukin-2 mutein VIS171 in a nonhuman primate model.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

American Journal of Transplantation at 25 years: A trusted voice.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

Profiling Allogeneic HLA-specific B-cell Responses Utilizing a 64-plex Single-HLA Reporter Cell Panel.

bioRxiv : the preprint server for biology·2026
Same author

Dual costimulation blockade with the CD154-specific fusion protein dazodalibep and belatacept for prophylaxis of kidney allograft rejection.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Corrigendum.

The Journal of allergy and clinical immunology·2026
Same journal

Comparative Efficacy of Biologic Agents for Severe Chronic Rhinosinusitis with Nasal Polyps: A Systematic Review and Network Meta-analysis.

The Journal of allergy and clinical immunology·2026
Same journal

Tamoxifen-driven neutrophil reprogramming protects from pulmonary Granulibacter bethesdensis infection in chronic granulomatous disease.

The Journal of allergy and clinical immunology·2026
Same journal

Clinical and transcriptomic characterization of mixed granulocytic COPD phenotype.

The Journal of allergy and clinical immunology·2026
Same journal

Dupilumab outcomes in pediatric asthma by early eosinophil status: post hoc analysis of VOYAGE/EXCURSION.

The Journal of allergy and clinical immunology·2026
Same journal

Maternal antibiotic exposure alters the newborn metabolomic profile and increases the risk of respiratory infections in offspring: a 13-year longitudinal birth cohort study.

The Journal of allergy and clinical immunology·2026
See all related articles

Related Experiment Video

Updated: Sep 20, 2025

Isolation and Transplantation of Different Aged Murine Thymic Grafts.
05:47

Isolation and Transplantation of Different Aged Murine Thymic Grafts.

Published on: May 13, 2015

14.1K

Introducing thymus for promoting transplantation tolerance.

Zachary W Fitch1, Lillian Kang1, Jie Li2

  • 1Department of Surgery, Duke University Medical Center, Durham, NC.

The Journal of Allergy and Clinical Immunology
|June 11, 2022
PubMed
Summary
This summary is machine-generated.

Transplanting thymus tissue with organs may induce immune tolerance, a key goal in transplantation. This approach shows promise for future organ transplantation tolerance strategies.

Keywords:
DiGeorge syndromeT cellsThymus transplantationorgan transplantationtolerance

More Related Videos

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

14.5K
Isolation, Identification, and Purification of Murine Thymic Epithelial Cells
07:20

Isolation, Identification, and Purification of Murine Thymic Epithelial Cells

Published on: August 8, 2014

32.4K

Related Experiment Videos

Last Updated: Sep 20, 2025

Isolation and Transplantation of Different Aged Murine Thymic Grafts.
05:47

Isolation and Transplantation of Different Aged Murine Thymic Grafts.

Published on: May 13, 2015

14.1K
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

14.5K
Isolation, Identification, and Purification of Murine Thymic Epithelial Cells
07:20

Isolation, Identification, and Purification of Murine Thymic Epithelial Cells

Published on: August 8, 2014

32.4K

Area of Science:

  • Immunology
  • Transplantation Biology
  • Regenerative Medicine

Background:

  • Inducing immune tolerance is a critical challenge in organ transplantation.
  • Thymic tissue is fundamental for establishing central immune tolerance.
  • Cotransplantation of thymus with organs is a strategy explored for tolerance induction.

Purpose of the Study:

  • To review the history and current applications of thymus cotransplantation in organ transplantation.
  • To discuss the potential of allogeneic processed thymus tissue for tolerance induction.
  • To examine the use of processed thymus tissue in treating congenital athymia.

Main Methods:

  • Review of historical and current literature on thymus transplantation for tolerance.
  • Analysis of studies involving cotransplantation of thymic tissue with solid organs.
  • Evaluation of clinical experience with allogeneic processed thymus tissue for congenital athymia.

Main Results:

  • Thymic tissue possesses the inherent capacity to induce tolerance to donor-matched organs.
  • Previous studies explored various forms of thymus grafting for tolerance induction.
  • Processed thymus tissue has shown efficacy in treating congenital athymia, including DiGeorge syndrome.

Conclusions:

  • Thymus cotransplantation is a historically significant strategy for inducing transplant tolerance.
  • Allogeneic processed thymus tissue offers a potential novel approach for future tolerance induction research in organ transplantation.
  • Further investigation is warranted to explore the full potential of processed thymus tissue in transplantation.