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Updated: Sep 20, 2025

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A blueprint for examining striatal control of cognition
Elizabeth N Holly1, Edgar Díaz-Hernández1, Marc V Fuccillo1
1Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Abstract:
In a recent study, Bolkan, Stone, and colleagues demonstrated that direct and indirect striatal pathways in mice exert opponent control over choice behavior in a task- and state-dependent manner. This work highlights the need for rigorously controlled behavioral experiments and novel behavioral modeling in investigations of the neural mechanisms of decision making.
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