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Transcatheter Aortic Bioprosthesis Durability: A Single-Center Experience
Francesco Moroni1, Francesca Ziviello2, Francesco Federico1
1Università Vita-Salute San Raffaele, Milan, Italy.
Summary
Transcatheter aortic valve implant (TAVI) bioprostheses show excellent durability in an unselected patient cohort. This study evaluated mid-term outcomes, finding robust performance in patients with severe aortic valve stenosis.
Area of Science:
- Cardiology
- Interventional Cardiology
- Biomaterials Science
Background:
- Transcatheter aortic valve implant (TAVI) is increasingly used for severe aortic valve stenosis.
- Indications for TAVI are expanding to lower-risk patients with longer life expectancies.
- Bioprosthetic valve durability is a critical factor for these patients.
Purpose of the Study:
- To evaluate the mid-term durability and outcomes of TAVI bioprostheses.
- To assess all-cause death and bioprosthetic valve failure (BVF) in a high-volume single-center cohort.
- To analyze structural valve deterioration (SVD) and valve-related mortality.
Main Methods:
- Analysis of 408 consecutive patients undergoing transfemoral TAVI between 2007 and 2014.
- Long-term follow-up including clinical assessment and echocardiography (limited).
- Adherence to international standards for defining SVD and BVF.
Main Results:
- Median follow-up of 1821 days revealed 64.5% overall mortality.
- Bioprosthetic valve failure (BVF) occurred in 17 patients, with 15 requiring reintervention.
- Moderate/severe SVD observed in 10/7 patients; echocardiographic subgroup showed no significant gradient or regurgitation increase.
Conclusions:
- TAVI bioprostheses demonstrate excellent durability in an unselected, all-comers population at long-term follow-up.
- The findings support the use of TAVI in a broader patient demographic.
- Mid-term performance indicates favorable valve longevity.
