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Published on: August 15, 2018
Hemodynamic consequences of respiratory interventions in preterm infants
Arvind Sehgal1,2, J Lauren Ruoss3, Amy H Stanford4
1Monash Newborn, Monash Children's Hospital, Melbourne, VIC, Australia. Arvind.Sehgal@monash.edu.
Insights
Premature infants are vulnerable to hemodynamic changes from respiratory support. This review details the impact of neonatal respiratory care on preterm infant hemodynamics and suggests assessment tools.
Area of Science:
- Neonatology
- Pediatric Cardiology
- Perinatal Medicine
Background:
- Perinatal management advances improve preterm infant survival.
- Preterm infants experience rapid circulatory changes post-birth.
- Immature cardiovascular systems in preterm infants are vulnerable to hemodynamic effects.
Purpose of the Study:
- To outline the vulnerability of preterm infants to hemodynamic disturbances.
- To describe the hemodynamic effects of common respiratory practices in neonates.
- To identify tools for assessing cardiopulmonary interactions and guiding management.
Main Methods:
- Narrative review of existing literature.
- Focus on hemodynamic impacts of respiratory interventions.
- Discussion of diagnostic and therapeutic strategies.
Main Results:
- Routine respiratory interventions can negatively affect preterm infant heart function and hemodynamics.
- The hemodynamic impact of standard neonatal respiratory care is not fully understood.
- Preterm infants, especially those at the limits of viability, are susceptible.
Conclusions:
- Enhanced diagnostic precision and judicious therapeutic approaches are needed.
- Understanding cardiopulmonary interactions is crucial for managing preterm infants.
- Respiratory care requires careful consideration of hemodynamic consequences in neonates.
Abstract:
Advances in perinatal management have led to improvements in survival rates for premature infants. It is known that the transitional period soon after birth, and the subsequent weeks, remain periods of rapid circulatory changes. Preterm infants, especially those born at the limits of viability, are susceptible to hemodynamic effects of routine respiratory care practices. In particular, the immature myocardium and cardiovascular system is developmentally vulnerable. Standard of care (but essential) respiratory interventions, administered as part of neonatal care, may negatively impact heart function and/or pulmonary or systemic hemodynamics. The available evidence regarding the hemodynamic impact of these respiratory practices is not well elucidated. Enhanced diagnostic precision and therapeutic judiciousness are warranted. In this narrative, we outline (1) the vulnerability of preterm infants to hemodynamic disturbances (2) the hemodynamic effects of common respiratory practices; including positive pressure ventilation and surfactant therapy, and (3) identify tools to assess cardiopulmonary interactions and guide management.
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