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Synchronous multiple primary tumors in patients with malignant lymphoma: a retrospective study
Yu Yagi1, Yusuke Kanemasa2, Yuki Sasaki3
1Department of Medical Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, 3-18-22 Hon-komagome, Bunkyo-ku, Tokyo, 113-8677, Japan.
BMC Cancer
|June 11, 2022
Summary
Synchronous multiple primary malignant tumors (sMPMTs) worsen prognosis in indolent lymphoma patients, primarily due to solid tumor mortality. sMPMTs do not significantly impact diffuse large B-cell lymphoma (DLBCL) outcomes.
Area of Science:
- Oncology
- Hematology
- Cancer Research
Background:
- Synchronous multiple primary malignant tumors (sMPMTs) can co-occur with malignant lymphoma.
- Investigating the prognostic significance of sMPMTs in lymphoma patients is crucial for treatment strategies.
Purpose of the Study:
- To evaluate the prognostic impact of sMPMTs in lymphoma patients.
- To determine optimal treatment strategies for lymphoma patients with sMPMTs.
Main Methods:
- Retrospective analysis of 1285 lymphoma patients diagnosed between August 2004 and April 2020.
- Identified 75 patients (5.8%) with sMPMTs.
Main Results:
- Indolent lymphoma patients with sMPMTs showed worse overall survival (OS) (5-year OS: 73.4% vs. 87.8%, P=0.047) and higher death rates from solid tumors.
- Diffuse large B-cell lymphoma (DLBCL) patients with sMPMTs had similar OS and progression-free survival (PFS) but a higher cumulative rate of death from solid tumors (5-year cumulative rate: 7.4% vs. 2.1%, P=0.004).
- Treatment sequence did not significantly affect outcomes or chemotherapy dose intensity.
Conclusions:
- sMPMTs significantly worsen prognosis in indolent lymphoma, mainly due to increased solid tumor mortality.
- sMPMTs are not a significant prognostic factor in DLBCL.
- Early assessment and treatment of all malignancies in sMPMT patients are essential.
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