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Enhancing the Trustworthiness of the Endocrine Society's Clinical Practice Guidelines
Christopher R McCartney1, Maureen D Corrigan2, Matthew T Drake3
1Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
The Journal of Clinical Endocrinology and Metabolism
|June 12, 2022
Summary
The Endocrine Society enhanced its clinical practice guidelines using rigorous methods and the GRADE approach. These updates improve guideline trustworthiness and clarity for readers.
Area of Science:
- Endocrinology
- Clinical Practice Guidelines
- Health Policy
Background:
- Clinical practice guidelines are crucial for evidence-based medicine.
- Ensuring the trustworthiness and transparency of guidelines is paramount.
- The Endocrine Society has undertaken significant revisions to its guideline development process.
Purpose of the Study:
- To communicate recent enhancements in the Endocrine Society's clinical practice guideline development policies and methodologies.
- To explain the rationale behind these improvements, emphasizing adherence to the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach.
- To highlight key changes designed to increase guideline reliability and reader understanding.
Main Methods:
- Adoption of new policies and rigorous methodologies for guideline development.
- Increased inclusion of non-endocrinologist experts and patient representatives on panels.
- Implementation of a strict conflict of interest policy.
- Mandatory systematic evidence reviews for all formal recommendations.
- Explicit use of GRADE Evidence-to-Decision frameworks.
- Standardization of guideline language and a structured approach to guideline updating.
Main Results:
- Guidelines now feature enhanced inclusion of diverse expertise and stricter conflict of interest management.
- Recommendations are explicitly linked to systematic evidence reviews.
- The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) methodology is more deeply integrated.
- Guideline language is more standardized, and updating processes are more systematic.
- Readers can expect a more transparent and reliable guideline experience.
Conclusions:
- The Endocrine Society has implemented substantial improvements to its clinical practice guideline development.
- These enhancements, particularly the adoption of the GRADE approach, aim to bolster guideline trustworthiness and utility.
- The revised processes are expected to result in clearer, more reliable, and reader-friendly clinical practice guidelines.
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