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Updated: Sep 8, 2025

Retinal Pathophysiological Evaluation in a Rat Model
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Retinal Pathophysiological Evaluation in a Rat Model

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Presumed retinal lead poisoning: a case report.

Fatemeh Bazvand1, Zahra Mahdizad2

  • 1Retina and Vitreous Service, Farabi Comprehensive Center of Excellence in Ophthalmology, Tehran University of Medical Sciences, Qazvin square, Tehran, 1336616351, Iran.

Documenta Ophthalmologica. Advances in Ophthalmology
|June 12, 2022
PubMed
Summary

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Diagnostic value of congenital hypertrophy of the retinal pigment epithelium in familial adenomatous polyposis: a systematic review.

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This study details a case of presumed early-onset retinal lead poisoning in a 42-year-old male experiencing vision loss. Findings include characteristic retinal changes and reduced electroretinogram responses, confirming lead toxicity.

Area of Science:

  • Ophthalmology
  • Toxicology
  • Retinal Diseases

Background:

  • Systemic lead poisoning can manifest with ocular complications.
  • Retinal involvement in lead poisoning, while known, requires detailed case documentation.

Observation:

  • A 42-year-old male presented with bilateral reduced vision after systemic lead exposure.
  • Comprehensive ophthalmic examinations were performed, including imaging and electrophysiology.

Findings:

  • Fundus examination revealed venous tortuosity, macular atrophy, and pigmentary changes.
  • Optical coherence tomography (OCT) showed retinal thinning, outer retinal atrophy, RPE atrophy, and foveal schisis.
  • Autofluorescence and fluorescein angiography demonstrated a leopard-like pattern and hypoautofluorescence.
Keywords:
Chronic lead poisoningLead toxicityRetinal degenerationRetinal lead poisoning

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  • Electroretinography indicated reduced photopic and scotopic responses.

    • Implications:

    • This case highlights the potential for early-onset retinal manifestations of lead poisoning.
    • The findings underscore the importance of thorough ophthalmologic evaluation in patients with suspected lead toxicity.
    • Early diagnosis and management are crucial to prevent irreversible vision impairment.