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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
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[Association between periodontitis and mild cognitive impairment: a clinical pilot study]
1Department of Periodontology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine & College of Stomatology, Shanghai Jiao Tong University & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Shanghai Key Laboratory of Stomatology, Shanghai 200011, China.
Summary
Moderate to severe periodontitis is strongly linked to mild cognitive impairment (MCI) in older adults. Poor oral hygiene and severe gum inflammation are potential risk factors for MCI.
Area of Science:
- Periodontology
- Neurology
- Public Health
Background:
- Periodontitis, a chronic inflammatory disease, affects a significant portion of the adult population.
- Mild cognitive impairment (MCI) represents an intermediate stage between normal cognitive aging and dementia.
- Understanding the link between oral health and cognitive function is crucial for preventative strategies.
Purpose of the Study:
- To investigate the association between periodontitis and mild cognitive impairment (MCI).
- To identify potential oral health risk factors contributing to MCI in middle-aged and elderly individuals.
Main Methods:
- A case-control study involving 70 subjects with periodontal disease, divided into MCI and control groups.
- Comprehensive periodontal examinations, including probing depth and indices, were conducted.
- Cognitive function was assessed using the mini-mental state examination scale; serum inflammatory markers were also analyzed.
Main Results:
- Subjects with moderate to severe periodontitis were significantly more likely to have MCI (OR=3.00).
- Deeper periodontal pockets (PD≥6 mm), a higher number of PD≥4 mm, and poorer gingival index scores were associated with MCI.
- No significant differences in serum inflammatory factors (hs-CRP, IL-1β, IL-6, TNF-α) were found between groups.
Conclusions:
- Moderate to severe periodontitis is a significant risk factor for MCI in middle-aged and elderly populations.
- Clinical indicators of periodontitis, such as deep pockets and severe gingival inflammation, are potential risk factors for MCI.
- Further research is needed to elucidate the underlying mechanisms connecting periodontitis and cognitive decline.
