Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ribosome Profiling02:24

Ribosome Profiling

3.6K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
3.6K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

173
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
173
Introduction to R01:11

Introduction to R

581
R is a powerful software environment for statistical computing and graphics. Originating as an implementation of the S language, developed at Bell Laboratories, R has evolved into a robust, open-source statistical software favored by statisticians and data scientists worldwide. Its comprehensive suite includes data manipulation, calculation, and graphical display capabilities, making it versatile for data analysis and visualization. Its programming language is at the core of R's...
581
Methods of Documentation II: POMR01:26

Methods of Documentation II: POMR

1.1K
The Problem-Oriented Medical Record (POMR) revolutionized medical record-keeping by introducing a systematic approach focusing on the patient's problems rather than merely listing symptoms. Dr. Lawrence Weed's introduction of this method in the 1960s marked a significant advancement in medical documentation. The POMR framework consists of four key components: the database, problem list, plan of care, and progress notes.
1.1K
Three Developmental Domains01:29

Three Developmental Domains

325
Human development is typically examined across three main domains: physical, cognitive, and socio-emotional. These domains represent the significant areas of change and continuity throughout the lifespan, from infancy to late adulthood.
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and weight,...
325
Protein Folding Quality Check in the RER01:29

Protein Folding Quality Check in the RER

3.8K
ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advancing precision psychiatry and targeted treatments: Insights from immunopsychiatry.

Brain, behavior, and immunity·2025
Same author

Development and environment in the National Institute of Mental Health (NIMH) Research Domain Criteria.

Journal of psychopathology and clinical science·2022
Same author

Revisiting the seven pillars of RDoC.

BMC medicine·2022
Same author

Posttraumatic stress symptom dimensions and brain responses to startling auditory stimuli in combat veterans.

Journal of abnormal psychology·2021
Same author

Evolving Concepts of the Schizophrenia Spectrum: A Research Domain Criteria Perspective.

Frontiers in psychiatry·2021
Same author

The role of RDoC in future classification of mental disorders
.

Dialogues in clinical neuroscience·2020
Same journal

Facing ambiguity: What we do in the space between stimulus and response.

Current directions in psychological science·2026
Same journal

Escaping the Jingle-Jangle Jungle: Increasing Conceptual Clarity in Psychology Using Large Language Models.

Current directions in psychological science·2026
Same journal

Emotional Acculturation: Emotions as a Pathway to Social Integration.

Current directions in psychological science·2026
Same journal

Historical Change in Midlife Development from a Cross-National Perspective.

Current directions in psychological science·2026
Same journal

Embodied and Embedded Learning: Child, Caregiver, and Context.

Current directions in psychological science·2026
Same journal

A Framework for Automation in Psychotherapy.

Current directions in psychological science·2025
See all related articles

Related Experiment Video

Updated: Sep 8, 2025

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes
07:55

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes

Published on: May 31, 2011

10.5K

Research Domain Criteria (RDoC): Progress and Potential.

Bruce N Cuthbert1

  • 1National Institute of Mental Health.

Current Directions in Psychological Science
|June 13, 2022
PubMed
Summary
This summary is machine-generated.

The National Institute of Mental Health developed the Research Domain Criteria (RDoC) project to improve translational research in mental illness by focusing on behavioral and neurobiological dimensions rather than traditional diagnostic categories.

Keywords:
RDoCResearch Domain Criteriacomputational psychiatryexperimental psychopathologypsychological constructs

More Related Videos

Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study
07:50

Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study

Published on: April 18, 2025

398
Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting
06:16

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting

Published on: June 6, 2020

3.8K

Related Experiment Videos

Last Updated: Sep 8, 2025

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes
07:55

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes

Published on: May 31, 2011

10.5K
Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study
07:50

Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study

Published on: April 18, 2025

398
Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting
06:16

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting

Published on: June 6, 2020

3.8K

Area of Science:

  • Psychiatry
  • Neuroscience
  • Psychopathology

Background:

  • The current diagnostic system for mental illness hinders translational research due to heterogeneous disorder categories.
  • Peer review practices prioritize existing diagnostic categories, limiting innovation in mental illness research.

Purpose of the Study:

  • To address limitations in current diagnostic systems and advance translational research in mental illness.
  • To develop new frameworks for studying psychopathology based on measurable behavioral and neurobiological dimensions.

Main Methods:

  • The Research Domain Criteria (RDoC) project was established to create a new research framework.
  • RDoC focuses on empirically-derived dimensions of behavior and neurobiology (e.g., reward valuation, working memory).
  • The framework integrates data across behavioral, biological, and self-report measures, considering neurodevelopment and environmental factors.

Main Results:

  • The RDoC project has progressed over its first decade, building a literature base for new conceptions of mental illness.
  • The framework encourages full-range dimensional approaches, from typical to abnormal functioning.
  • Progress is linked to advancements in psychological measurement and integrative brain-behavior relationship studies.

Conclusions:

  • The RDoC project offers a novel approach to understanding mental illness by moving beyond traditional diagnostic categories.
  • It aims to inform future revisions of diagnostic manuals and foster more effective translational research.
  • The project's foundation in experimental psychopathology and integrative neuroscience provides a robust platform for future research.