Related Experiment Video
Updated: Sep 8, 2025
07:16
Author Spotlight: Development of a Novel Finite Element Analysis Model for Improved Orthognathic Surgical Techniques
Published on: October 20, 2023
1.4K
A Comparative Histomorphometric Analysis of Two Biomaterials for Maxillary Sinus Augmentation: A Randomized Clinical,
Carlos Ricardo de Queiroz Martiniano1,2,3, Lídia Audrey Rocha Valadas4, Jose Ronildo Lins do Carmo Filho2
1São Leopoldo Mandic Institute and Research Center, São Paulo, Brazil.
Summary
Bio-Oss® demonstrated superior bone regeneration compared to Lumina-Porous® in maxillary sinus augmentation. Both bovine biomaterials facilitated bone neoformation, but Bio-Oss® resulted in significantly more vital mineralized bone tissue after nine months.
Area of Science:
- Biomaterials Science
- Oral and Maxillofacial Surgery
- Regenerative Medicine
Background:
- Bone regeneration is crucial for successful oral rehabilitation with dental implants.
- Various biomaterials are continuously developed to enhance bone formation in augmentation procedures.
- Maxillary sinus augmentation is a common procedure requiring effective bone graft materials.
Purpose of the Study:
- To compare bone neoformation in patients undergoing maxillary sinus surgery using two different bovine biomaterials.
- To evaluate the efficacy of Bio-Oss® versus Lumina-Porous® in promoting new bone growth.
- To assess histological differences in bone and connective tissue regeneration between the two grafts.
Main Methods:
- A randomized, blinded, clinical crossover, divided mouth study was conducted on ten participants.
- Participants received Bio-Oss® graft on one side and Lumina-Porous® graft on the other side of the maxillary sinus.
- Histological analysis of bone and connective tissue was performed after nine months, including decalcification and slide preparation.
Main Results:
- Bio-Oss® group showed significantly greater formation of vital mineralized tissue (p=0.01).
- No significant differences were observed in non-vital mineralized tissue or connective tissue amounts (p=0.21, p=0.09).
- Higher percentages of osteoclasts and viable osteocytes were found in the Bio-Oss® group (p=0.014, p=0.027).
Conclusions:
- Both Bio-Oss® and Lumina-Porous® induced bone neoformation following maxillary sinus augmentation.
- Bio-Oss® demonstrated a higher capacity for generating vital mineralized bone tissue compared to Lumina-Porous®.
- The findings suggest Bio-Oss® may be a more effective biomaterial for bone regeneration in this context.
