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Deubiquitinase JOSD1 promotes tumor progression via stabilizing Snail in lung adenocarcinoma

Xingjie Ma1, Weibo Qi1, Fan Yang1

  • 1Department of Cardiothoracic Surgery, First Affiliated Hospital of Jiaxing University Jiaxing 314001, Zhejiang, China.

American Journal of Cancer Research
|June 13, 2022
PubMed

Insights

The deubiquitinase JOSD1 is overexpressed in lung adenocarcinoma (LUAD), promoting tumor metastasis by stabilizing Snail. Targeting JOSD1 may offer a new therapeutic strategy for LUAD patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • The deubiquitinase JOSD1 is implicated in cancer aggressiveness.
  • The role of JOSD1 in lung adenocarcinoma (LUAD) remains unclear.

Purpose of the Study:

  • To investigate the role and mechanism of JOSD1 in LUAD progression.

Main Methods:

  • Assessed JOSD1 expression in LUAD tissues.
  • Correlated JOSD1 levels with clinicopathological features and patient survival.
  • Examined the effect of JOSD1 knockdown and overexpression on LUAD cell proliferation and metastasis.
  • Investigated the interaction between JOSD1 and Snail protein.

Main Results:

  • JOSD1 was significantly overexpressed in LUAD tissues compared to normal tissues.
  • High JOSD1 levels correlated with advanced clinicopathological characteristics and poor overall survival (OS).
  • JOSD1 knockdown inhibited LUAD cell proliferation and metastasis; overexpression enhanced these phenotypes.
  • JOSD1 deubiquitinates and stabilizes Snail, promoting epithelial-to-mesenchymal transition (EMT), invasion, and metastasis.
  • JOSD1 expression positively correlated with Snail expression in LUAD tissues.
  • Co-overexpression of JOSD1 and Snail predicted the worst prognosis.

Conclusions:

  • JOSD1 is a key driver of LUAD metastasis by stabilizing Snail through deubiquitination.
  • JOSD1 overexpression is associated with unfavorable prognosis in LUAD patients.
  • JOSD1 represents a potential therapeutic target for inhibiting LUAD progression.
Keywords:
EMTJOSD1Lung adenocarcinomaSnailmetastasis

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