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Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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PanaxGDB: A Comprehensive Platform for Panax.

Yuan Lin1,2,3, Bing Hao1,2, Ying Chun Lu1,2

  • 1State Key Laboratory of Conservation and Utilization of Bio-Resources in Yunnan, The Key Laboratory of Medicinal Plant Biology of Yunnan Province, National & Local Joint Engineering Research Center on Germplasms Innovation & Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University, Kunming, China.

Frontiers in Plant Science
|June 13, 2022
PubMed
Summary

PanaxGDB is a new comprehensive database integrating omics data and variety information for the valuable Panax genus. This resource aids researchers by consolidating scattered data, promoting integrated analysis for ginseng and related species.

Keywords:
Panaxcultivarsdatabasegenomesaponins

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Area of Science:

  • Plant genomics
  • Bioinformatics
  • Natural products chemistry

Background:

  • The Panax genus, including ginseng, American ginseng, and Sanqi, is a globally important medicinal resource rich in bioactive triterpenoid saponins.
  • Extensive omics data and cultivar information have been generated for key Panax species using molecular biotechnology and breeding techniques.
  • Existing data are fragmented and potentially redundant, hindering integrated analysis and efficient research.

Purpose of the Study:

  • To establish a centralized, reliable, and comprehensive omics database for the Panax genus.
  • To facilitate integrated analysis of diverse biological and agronomic data within the Panax genus.
  • To support research on saponin biosynthesis, quality improvement, and cultivation of Panax species.

Main Methods:

  • Development of PanaxGDB, an open-access database integrating omics data, variety information, and analytical tools.
  • Compilation of data including nearly 600 compounds, draft genomic sequences, gene expression levels, SNPs, and germplasm information.
  • Inclusion of genome-wide association analysis results for agronomic traits.

Main Results:

  • PanaxGDB provides access to extensive data for 12 Panax species.
  • The database incorporates genomic sequences, gene expression, SNPs, germplasm data, and compound information.
  • Integrated analytical tools are available for versatile data exploration.

Conclusions:

  • PanaxGDB serves as a crucial central portal for Panax research, consolidating diverse data types.
  • The database aims to save researchers time and promote integrated analysis of Panax biology and functions.
  • Continuous updates will ensure PanaxGDB remains a valuable, evolving resource for the scientific community.